Contribution of neutrophils in the pathogenesis of rheumatoid arthritis

Lingshu Zhang, Yi Yuan, Qiang Xu, Zhengyu Jiang, Cong Qiu Chu

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Neutrophils are major innate immune effector cells for host defense and have been a topic of active research for their participation in the pathogenesis of autoimmune inflammatory diseases including rheumatoid arthritis (RA) due to recently discovered neutrophil extracellular trap (NET) formation. NET formation and other mechanisms leading to the release of neutrophil nuclear and cytoplasmic contents are implicated as a source of citrullinated antigens in RA. Further investigations are required to delineate what factors diverge neutrophils from host defense to autoimmune response in RA.

Original languageEnglish (US)
Article number0075
Pages (from-to)86-93
Number of pages8
JournalJournal of Biomedical Research
Volume34
Issue number2
DOIs
StatePublished - Apr 1 2020

Keywords

  • NET formation
  • Neutrophils
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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