Contribution of horizontal gene transfer and deletion events to development of distinctive patterns of fimbrial operons during evolution of Salmonella serotypes

Andreas J. Bäumler, Andries J. Gilde, Renée M. Tsolis, Adrianus W M Van Der Velden, Brian M M Ahmer, Fred Heffron

    Research output: Contribution to journalArticle

    87 Citations (Scopus)

    Abstract

    Only certain serotypes of Salmonella represent 99% of all human clinical isolates. We determined whether the phylogenetic distribution of fimbrial operons would account for the host adaptations observed for Salmonella serotypes. We found that three fimbrial operons, fim, lpf, and agf, were present in a lineage ancestral to Salmonella. While the fim and agf fimbrial operons were highly conserved among all Salmonella serotypes, sequence analysis suggested that the lpf operon was lost from many distantly related lineages. As a consequence, the distribution of the lpf operon cannot be explained easily and may be a consequence of positive and negative selection in different hosts for the presence of these genes. Two other fimbrial operons, sef and pef, each entered two distantly related Salmonella lineages and each is present only in a small number of serotypes. These results show that horizontal gene transfer and deletion events have created unique combinations of fimbrial operons among Salmonella serotypes. The presence of sef and pef correlated with serotypes frequently isolated from common domesticated animals.

    Original languageEnglish (US)
    Pages (from-to)317-322
    Number of pages6
    JournalJournal of Bacteriology
    Volume179
    Issue number2
    StatePublished - 1997

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    Horizontal Gene Transfer
    Gene Deletion
    Operon
    Salmonella
    Domestic Animals
    Serogroup
    Sequence Analysis
    Genes

    ASJC Scopus subject areas

    • Applied Microbiology and Biotechnology
    • Immunology

    Cite this

    Bäumler, A. J., Gilde, A. J., Tsolis, R. M., Van Der Velden, A. W. M., Ahmer, B. M. M., & Heffron, F. (1997). Contribution of horizontal gene transfer and deletion events to development of distinctive patterns of fimbrial operons during evolution of Salmonella serotypes. Journal of Bacteriology, 179(2), 317-322.

    Contribution of horizontal gene transfer and deletion events to development of distinctive patterns of fimbrial operons during evolution of Salmonella serotypes. / Bäumler, Andreas J.; Gilde, Andries J.; Tsolis, Renée M.; Van Der Velden, Adrianus W M; Ahmer, Brian M M; Heffron, Fred.

    In: Journal of Bacteriology, Vol. 179, No. 2, 1997, p. 317-322.

    Research output: Contribution to journalArticle

    Bäumler, AJ, Gilde, AJ, Tsolis, RM, Van Der Velden, AWM, Ahmer, BMM & Heffron, F 1997, 'Contribution of horizontal gene transfer and deletion events to development of distinctive patterns of fimbrial operons during evolution of Salmonella serotypes', Journal of Bacteriology, vol. 179, no. 2, pp. 317-322.
    Bäumler, Andreas J. ; Gilde, Andries J. ; Tsolis, Renée M. ; Van Der Velden, Adrianus W M ; Ahmer, Brian M M ; Heffron, Fred. / Contribution of horizontal gene transfer and deletion events to development of distinctive patterns of fimbrial operons during evolution of Salmonella serotypes. In: Journal of Bacteriology. 1997 ; Vol. 179, No. 2. pp. 317-322.
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    abstract = "Only certain serotypes of Salmonella represent 99{\%} of all human clinical isolates. We determined whether the phylogenetic distribution of fimbrial operons would account for the host adaptations observed for Salmonella serotypes. We found that three fimbrial operons, fim, lpf, and agf, were present in a lineage ancestral to Salmonella. While the fim and agf fimbrial operons were highly conserved among all Salmonella serotypes, sequence analysis suggested that the lpf operon was lost from many distantly related lineages. As a consequence, the distribution of the lpf operon cannot be explained easily and may be a consequence of positive and negative selection in different hosts for the presence of these genes. Two other fimbrial operons, sef and pef, each entered two distantly related Salmonella lineages and each is present only in a small number of serotypes. These results show that horizontal gene transfer and deletion events have created unique combinations of fimbrial operons among Salmonella serotypes. The presence of sef and pef correlated with serotypes frequently isolated from common domesticated animals.",
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    T1 - Contribution of horizontal gene transfer and deletion events to development of distinctive patterns of fimbrial operons during evolution of Salmonella serotypes

    AU - Bäumler, Andreas J.

    AU - Gilde, Andries J.

    AU - Tsolis, Renée M.

    AU - Van Der Velden, Adrianus W M

    AU - Ahmer, Brian M M

    AU - Heffron, Fred

    PY - 1997

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    N2 - Only certain serotypes of Salmonella represent 99% of all human clinical isolates. We determined whether the phylogenetic distribution of fimbrial operons would account for the host adaptations observed for Salmonella serotypes. We found that three fimbrial operons, fim, lpf, and agf, were present in a lineage ancestral to Salmonella. While the fim and agf fimbrial operons were highly conserved among all Salmonella serotypes, sequence analysis suggested that the lpf operon was lost from many distantly related lineages. As a consequence, the distribution of the lpf operon cannot be explained easily and may be a consequence of positive and negative selection in different hosts for the presence of these genes. Two other fimbrial operons, sef and pef, each entered two distantly related Salmonella lineages and each is present only in a small number of serotypes. These results show that horizontal gene transfer and deletion events have created unique combinations of fimbrial operons among Salmonella serotypes. The presence of sef and pef correlated with serotypes frequently isolated from common domesticated animals.

    AB - Only certain serotypes of Salmonella represent 99% of all human clinical isolates. We determined whether the phylogenetic distribution of fimbrial operons would account for the host adaptations observed for Salmonella serotypes. We found that three fimbrial operons, fim, lpf, and agf, were present in a lineage ancestral to Salmonella. While the fim and agf fimbrial operons were highly conserved among all Salmonella serotypes, sequence analysis suggested that the lpf operon was lost from many distantly related lineages. As a consequence, the distribution of the lpf operon cannot be explained easily and may be a consequence of positive and negative selection in different hosts for the presence of these genes. Two other fimbrial operons, sef and pef, each entered two distantly related Salmonella lineages and each is present only in a small number of serotypes. These results show that horizontal gene transfer and deletion events have created unique combinations of fimbrial operons among Salmonella serotypes. The presence of sef and pef correlated with serotypes frequently isolated from common domesticated animals.

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