Contribution of glial-neuronal interactions to the neuroendocrine control of female puberty

    Research output: Contribution to journalArticle

    34 Citations (Scopus)

    Abstract

    Mammalian puberty is initiated by an increased pulsatile release of the neuropeptide gonadotropin-releasing hormone (GnRH) from hypothalamic neuroendocrine neurons. Although this increase is primarily set in motion by neuronal networks synaptically connected to GnRH neurons, glial cells contribute to the process via at least two mechanisms. One involves production of growth factors acting via receptors endowed with either serine-threonine kinase or tyrosine kinase activity. The other involves plastic rearrangements of glia-GnRH neuron adhesiveness. Growth factors of the epidermal growth factor family acting via erbB receptors play a major role in glia-to-GnRH neuron communication. In turn, neurons facilitate astrocytic erbB signaling via glutamate-dependent cleavage of erbB ligand precursors. The genetic disruption of erbB receptors delays female sexual development due to impaired erbB ligand-induced glial prostaglandin E2 release. The adhesiveness of glial cells to GnRH neurons involves at least two different cell-cell communication systems endowed with both adhesive and intracellular signaling capabilities. One is provided by synaptic cell adhesion molecule (SynCAM1), which establishes astrocyte-GnRH neuron adhesiveness via homophilic interactions and the other involves the heterophilic interaction of neuronal contactin with glial receptor-like protein tyrosine phosphatase-β. These findings indicate that the interaction of glial cells with GnRH neurons involves not only secreted bioactive molecules, but also cell-surface adhesive proteins able to set in motion intracellular signaling cascades.

    Original languageEnglish (US)
    Pages (from-to)2003-2010
    Number of pages8
    JournalEuropean Journal of Neuroscience
    Volume32
    Issue number12
    DOIs
    StatePublished - Dec 2010

    Fingerprint

    Puberty
    Neuroglia
    Gonadotropin-Releasing Hormone
    Neurons
    Adhesiveness
    Adhesives
    Receptor-Like Protein Tyrosine Phosphatases
    Intercellular Signaling Peptides and Proteins
    Contactins
    Ligands
    Sexual Development
    Protein-Serine-Threonine Kinases
    Cell Adhesion Molecules
    Neuropeptides
    Dinoprostone
    Epidermal Growth Factor
    Cell Communication
    Astrocytes
    Protein-Tyrosine Kinases
    Plastics

    Keywords

    • Female sexual development
    • Glial cells
    • Glial-neuronal interactions
    • Hypothalamus
    • Intercellular signaling
    • Neuroendocrine neurons

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Contribution of glial-neuronal interactions to the neuroendocrine control of female puberty. / Ojeda, Sergio; Lomniczi, Alejandro; Sandau, Ursula.

    In: European Journal of Neuroscience, Vol. 32, No. 12, 12.2010, p. 2003-2010.

    Research output: Contribution to journalArticle

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