Contrast-enhanced ultrasound reveals real-time spatial changes in vascular perfusion during early implantation in the macaque uterus

Christopher S. Keator, Jonathan Lindner, J. Todd Belcik, Cecily Bishop, Ov Slayden

    Research output: Contribution to journalArticle

    23 Citations (Scopus)

    Abstract

    Objective: To use contrast-enhanced ultrasound (CEU) to quantify blood flow in the macaque uterus during early pregnancy. Design: Prospective nonhuman primate study. Setting: Oregon National Primate Research Center. Animals: Naturally cycling female rhesus macaques (Macaca mulatta). Intervention(s): Female macaques were mated on days 11-14 of the cycle. Females were then imaged by CEU and Doppler ultrasound once every 3 days from day 21 through day 39 of the fertile cycle. Main Outcome Measure(s): Visualization and quantification of uterine vascular perfusion. Result(s): CEU identified the primary placental disc and underlying vessels approximately 2 days earlier than Doppler ultrasound was able to observe endometrial thickening. CEU revealed spatial differences in vascular perfusion between the endometrium, myometrium, and endometrial- myometrial (junctional) zone. Myometrium displayed the highest rate of blood flow (>10 mL/min/g tissue). There was less blood flow in the endometrium and junctional zone (

    Original languageEnglish (US)
    JournalFertility and Sterility
    Volume95
    Issue number4
    DOIs
    StatePublished - Mar 15 2011

    Fingerprint

    Macaca
    Uterus
    Blood Vessels
    Doppler Ultrasonography
    Perfusion
    Myometrium
    Endometrium
    Macaca mulatta
    Primates
    Outcome Assessment (Health Care)
    Pregnancy
    Research

    Keywords

    • Contrast-enhanced ultrasound
    • Doppler ultrasound
    • endometrium
    • implantation
    • macaque
    • pregnancy
    • progesterone
    • uterus
    • vascular perfusion

    ASJC Scopus subject areas

    • Obstetrics and Gynecology
    • Reproductive Medicine

    Cite this

    @article{43af6716d18b48c6b2609cfd6dc8cbeb,
    title = "Contrast-enhanced ultrasound reveals real-time spatial changes in vascular perfusion during early implantation in the macaque uterus",
    abstract = "Objective: To use contrast-enhanced ultrasound (CEU) to quantify blood flow in the macaque uterus during early pregnancy. Design: Prospective nonhuman primate study. Setting: Oregon National Primate Research Center. Animals: Naturally cycling female rhesus macaques (Macaca mulatta). Intervention(s): Female macaques were mated on days 11-14 of the cycle. Females were then imaged by CEU and Doppler ultrasound once every 3 days from day 21 through day 39 of the fertile cycle. Main Outcome Measure(s): Visualization and quantification of uterine vascular perfusion. Result(s): CEU identified the primary placental disc and underlying vessels approximately 2 days earlier than Doppler ultrasound was able to observe endometrial thickening. CEU revealed spatial differences in vascular perfusion between the endometrium, myometrium, and endometrial- myometrial (junctional) zone. Myometrium displayed the highest rate of blood flow (>10 mL/min/g tissue). There was less blood flow in the endometrium and junctional zone (",
    keywords = "Contrast-enhanced ultrasound, Doppler ultrasound, endometrium, implantation, macaque, pregnancy, progesterone, uterus, vascular perfusion",
    author = "Keator, {Christopher S.} and Jonathan Lindner and Belcik, {J. Todd} and Cecily Bishop and Ov Slayden",
    year = "2011",
    month = "3",
    day = "15",
    doi = "10.1016/j.fertnstert.2011.01.040",
    language = "English (US)",
    volume = "95",
    journal = "Fertility and Sterility",
    issn = "0015-0282",
    publisher = "Elsevier Inc.",
    number = "4",

    }

    TY - JOUR

    T1 - Contrast-enhanced ultrasound reveals real-time spatial changes in vascular perfusion during early implantation in the macaque uterus

    AU - Keator, Christopher S.

    AU - Lindner, Jonathan

    AU - Belcik, J. Todd

    AU - Bishop, Cecily

    AU - Slayden, Ov

    PY - 2011/3/15

    Y1 - 2011/3/15

    N2 - Objective: To use contrast-enhanced ultrasound (CEU) to quantify blood flow in the macaque uterus during early pregnancy. Design: Prospective nonhuman primate study. Setting: Oregon National Primate Research Center. Animals: Naturally cycling female rhesus macaques (Macaca mulatta). Intervention(s): Female macaques were mated on days 11-14 of the cycle. Females were then imaged by CEU and Doppler ultrasound once every 3 days from day 21 through day 39 of the fertile cycle. Main Outcome Measure(s): Visualization and quantification of uterine vascular perfusion. Result(s): CEU identified the primary placental disc and underlying vessels approximately 2 days earlier than Doppler ultrasound was able to observe endometrial thickening. CEU revealed spatial differences in vascular perfusion between the endometrium, myometrium, and endometrial- myometrial (junctional) zone. Myometrium displayed the highest rate of blood flow (>10 mL/min/g tissue). There was less blood flow in the endometrium and junctional zone (

    AB - Objective: To use contrast-enhanced ultrasound (CEU) to quantify blood flow in the macaque uterus during early pregnancy. Design: Prospective nonhuman primate study. Setting: Oregon National Primate Research Center. Animals: Naturally cycling female rhesus macaques (Macaca mulatta). Intervention(s): Female macaques were mated on days 11-14 of the cycle. Females were then imaged by CEU and Doppler ultrasound once every 3 days from day 21 through day 39 of the fertile cycle. Main Outcome Measure(s): Visualization and quantification of uterine vascular perfusion. Result(s): CEU identified the primary placental disc and underlying vessels approximately 2 days earlier than Doppler ultrasound was able to observe endometrial thickening. CEU revealed spatial differences in vascular perfusion between the endometrium, myometrium, and endometrial- myometrial (junctional) zone. Myometrium displayed the highest rate of blood flow (>10 mL/min/g tissue). There was less blood flow in the endometrium and junctional zone (

    KW - Contrast-enhanced ultrasound

    KW - Doppler ultrasound

    KW - endometrium

    KW - implantation

    KW - macaque

    KW - pregnancy

    KW - progesterone

    KW - uterus

    KW - vascular perfusion

    UR - http://www.scopus.com/inward/record.url?scp=79952442418&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=79952442418&partnerID=8YFLogxK

    U2 - 10.1016/j.fertnstert.2011.01.040

    DO - 10.1016/j.fertnstert.2011.01.040

    M3 - Article

    VL - 95

    JO - Fertility and Sterility

    JF - Fertility and Sterility

    SN - 0015-0282

    IS - 4

    ER -