Contrast-Enhanced Ultrasound Molecular Imaging in Atherosclerosis Research

The Anh Nguyen, Jonathan R. Lindner

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The management of cardiovascular conditions will likely be improved by noninvasive in vivo molecular imaging technologies that can provide earlier or more accurate diagnosis. These techniques are already having a positive impact in preclinical research by providing insight into disease pathobiology or efficacy of new therapies. Contrast enhanced ultrasound (CEU) molecular imaging is a technique that relies on the ultrasound detection of targeted microbubble contrast agents to examine molecular or cellular events that occur at the blood pool-endothelial interface. For the most part, targeted contrast agents are composed of encapsulated gas microbubbles (MBs) that are 2–4 μm in diameter, or other acoustically active micro- or nanoparticles. These agents bear several tens of thousands of binding molecules per particle. Because nonadhered agent is cleared rapidly, CEU molecular imaging can be performed in a matter of minutes. MBs are detected using contrast-specific techniques that generate and receive nonlinear signals produced by MB cavitation, thereby increasing signal-to-noise ratio. Dedicated kinetic models for molecular imaging have been generated that permit the elimination of signal from nonadherent agent.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages801-808
Number of pages8
DOIs
StatePublished - 2022
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume2419
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Keywords

  • Atherosclerosis
  • Cavitation
  • Contrast-enhanced ultrasound
  • Microbubbles
  • Molecular imaging

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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