Contraceptive and therapeutic effects of the levonorgestrel intrauterine system: An overview

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

The levonorgestrel intrauterine system (LNG IUS), a steroid-releasing intrauterine system, is a T-shaped device that releases levonorgestrel directly into the uterine cavity at an initial rate of 20 μg per day. The contraceptive and therapeutic benefits of the LNG IUS stem primarily from its local effects. The local hormone delivery causes high levonorgestrel levels in the endometrial tissue but low levels in the systemic circulation. This leads to strong endometrial suppression and, in many cases, a dramatic reduction in menstrual blood loss. The high contraceptive efficacy is well documented through extensive international clinical research. This review article provides an overview of the LNG IUS and addresses the following topics: mechanisms of action, contraceptive efficacy, changes in bleeding patterns, principal safety issues, potential noncontraceptive benefits, and implications for women's reproductive health.

Original languageEnglish (US)
Pages (from-to)604-612
Number of pages9
JournalObstetrical and Gynecological Survey
Volume60
Issue number9
DOIs
StatePublished - Sep 2005

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Levonorgestrel
Therapeutic Uses
Contraceptive Agents
Reproductive Health
Women's Health
Steroids
Hormones
Hemorrhage
Safety
Equipment and Supplies
Research

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Contraceptive and therapeutic effects of the levonorgestrel intrauterine system : An overview. / Jensen, Jeffrey.

In: Obstetrical and Gynecological Survey, Vol. 60, No. 9, 09.2005, p. 604-612.

Research output: Contribution to journalArticle

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