Contraceptive and reproductive risk factors for cervical intraepithelial neoplasia in American Indian women

Melissa Schiff, Jill Miller, Mary Masuk, Linda Van Asselt King, Kathleen K. Altobelli, Cosette M. Wheeler, Thomas Becker

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Objectives. To evaluate contraceptive and reproductive risk factors for cervical intraepithelial neoplasia (CIN) in southwestern American Indian women. Methods. We conducted a clinic-based case-control study. Cases were American Indian women with biopsy-proven CIN I, CIN II or CIN III. Controls were from the same clinics and had normal cervical epithelium. All subjects underwent structured interviews focused on contraceptive and reproductive factors. Laboratory assays included polymerase chain reaction (PCR)-based tests for cervical human papillomavirus (HPV) infection. Results. We enrolled 628 women in the study. The strongest risk factors for CIN II/III included HPV infection (adjusted odds ratio [OR] = 7.9, 95% CI: 4.7-13.2), and low income (OR = 3.1, 95% CI: 1.7-5.7). The use of an intrauterine device (IUD) ever (OR = 3.0, 95% CI: 1.4-6.1) and currently (OR = 4.1, 95% CI: 1.1-14.6), and ≥3 vaginal deliveries (OR = 5.2, 95% CI : 2.4-11.1) were associated with CIN II/III. History of infertility was also associated with CIN II/III (OR = 2.1, 95% CI : 1.0-4.2). Conclusions. The data suggest that history of infertility, IUD use and vaginal deliveries were associated with CIN among American Indian women.

Original languageEnglish (US)
Pages (from-to)983-998
Number of pages16
JournalInternational Journal of Epidemiology
Volume29
Issue number6
StatePublished - 2000

Fingerprint

Cervical Intraepithelial Neoplasia
North American Indians
Contraceptive Agents
Odds Ratio
Intrauterine Devices
Papillomavirus Infections
Infertility
Case-Control Studies
Epithelium
Interviews
Biopsy
Polymerase Chain Reaction

Keywords

  • Cervix dysplasia
  • Cross cultural comparison
  • Indians North American

ASJC Scopus subject areas

  • Epidemiology

Cite this

Schiff, M., Miller, J., Masuk, M., Van Asselt King, L., Altobelli, K. K., Wheeler, C. M., & Becker, T. (2000). Contraceptive and reproductive risk factors for cervical intraepithelial neoplasia in American Indian women. International Journal of Epidemiology, 29(6), 983-998.

Contraceptive and reproductive risk factors for cervical intraepithelial neoplasia in American Indian women. / Schiff, Melissa; Miller, Jill; Masuk, Mary; Van Asselt King, Linda; Altobelli, Kathleen K.; Wheeler, Cosette M.; Becker, Thomas.

In: International Journal of Epidemiology, Vol. 29, No. 6, 2000, p. 983-998.

Research output: Contribution to journalArticle

Schiff, M, Miller, J, Masuk, M, Van Asselt King, L, Altobelli, KK, Wheeler, CM & Becker, T 2000, 'Contraceptive and reproductive risk factors for cervical intraepithelial neoplasia in American Indian women', International Journal of Epidemiology, vol. 29, no. 6, pp. 983-998.
Schiff M, Miller J, Masuk M, Van Asselt King L, Altobelli KK, Wheeler CM et al. Contraceptive and reproductive risk factors for cervical intraepithelial neoplasia in American Indian women. International Journal of Epidemiology. 2000;29(6):983-998.
Schiff, Melissa ; Miller, Jill ; Masuk, Mary ; Van Asselt King, Linda ; Altobelli, Kathleen K. ; Wheeler, Cosette M. ; Becker, Thomas. / Contraceptive and reproductive risk factors for cervical intraepithelial neoplasia in American Indian women. In: International Journal of Epidemiology. 2000 ; Vol. 29, No. 6. pp. 983-998.
@article{6c8dd3ea18464fc8a252afc5a2e030bb,
title = "Contraceptive and reproductive risk factors for cervical intraepithelial neoplasia in American Indian women",
abstract = "Objectives. To evaluate contraceptive and reproductive risk factors for cervical intraepithelial neoplasia (CIN) in southwestern American Indian women. Methods. We conducted a clinic-based case-control study. Cases were American Indian women with biopsy-proven CIN I, CIN II or CIN III. Controls were from the same clinics and had normal cervical epithelium. All subjects underwent structured interviews focused on contraceptive and reproductive factors. Laboratory assays included polymerase chain reaction (PCR)-based tests for cervical human papillomavirus (HPV) infection. Results. We enrolled 628 women in the study. The strongest risk factors for CIN II/III included HPV infection (adjusted odds ratio [OR] = 7.9, 95{\%} CI: 4.7-13.2), and low income (OR = 3.1, 95{\%} CI: 1.7-5.7). The use of an intrauterine device (IUD) ever (OR = 3.0, 95{\%} CI: 1.4-6.1) and currently (OR = 4.1, 95{\%} CI: 1.1-14.6), and ≥3 vaginal deliveries (OR = 5.2, 95{\%} CI : 2.4-11.1) were associated with CIN II/III. History of infertility was also associated with CIN II/III (OR = 2.1, 95{\%} CI : 1.0-4.2). Conclusions. The data suggest that history of infertility, IUD use and vaginal deliveries were associated with CIN among American Indian women.",
keywords = "Cervix dysplasia, Cross cultural comparison, Indians North American",
author = "Melissa Schiff and Jill Miller and Mary Masuk and {Van Asselt King}, Linda and Altobelli, {Kathleen K.} and Wheeler, {Cosette M.} and Thomas Becker",
year = "2000",
language = "English (US)",
volume = "29",
pages = "983--998",
journal = "International Journal of Epidemiology",
issn = "0300-5771",
publisher = "Oxford University Press",
number = "6",

}

TY - JOUR

T1 - Contraceptive and reproductive risk factors for cervical intraepithelial neoplasia in American Indian women

AU - Schiff, Melissa

AU - Miller, Jill

AU - Masuk, Mary

AU - Van Asselt King, Linda

AU - Altobelli, Kathleen K.

AU - Wheeler, Cosette M.

AU - Becker, Thomas

PY - 2000

Y1 - 2000

N2 - Objectives. To evaluate contraceptive and reproductive risk factors for cervical intraepithelial neoplasia (CIN) in southwestern American Indian women. Methods. We conducted a clinic-based case-control study. Cases were American Indian women with biopsy-proven CIN I, CIN II or CIN III. Controls were from the same clinics and had normal cervical epithelium. All subjects underwent structured interviews focused on contraceptive and reproductive factors. Laboratory assays included polymerase chain reaction (PCR)-based tests for cervical human papillomavirus (HPV) infection. Results. We enrolled 628 women in the study. The strongest risk factors for CIN II/III included HPV infection (adjusted odds ratio [OR] = 7.9, 95% CI: 4.7-13.2), and low income (OR = 3.1, 95% CI: 1.7-5.7). The use of an intrauterine device (IUD) ever (OR = 3.0, 95% CI: 1.4-6.1) and currently (OR = 4.1, 95% CI: 1.1-14.6), and ≥3 vaginal deliveries (OR = 5.2, 95% CI : 2.4-11.1) were associated with CIN II/III. History of infertility was also associated with CIN II/III (OR = 2.1, 95% CI : 1.0-4.2). Conclusions. The data suggest that history of infertility, IUD use and vaginal deliveries were associated with CIN among American Indian women.

AB - Objectives. To evaluate contraceptive and reproductive risk factors for cervical intraepithelial neoplasia (CIN) in southwestern American Indian women. Methods. We conducted a clinic-based case-control study. Cases were American Indian women with biopsy-proven CIN I, CIN II or CIN III. Controls were from the same clinics and had normal cervical epithelium. All subjects underwent structured interviews focused on contraceptive and reproductive factors. Laboratory assays included polymerase chain reaction (PCR)-based tests for cervical human papillomavirus (HPV) infection. Results. We enrolled 628 women in the study. The strongest risk factors for CIN II/III included HPV infection (adjusted odds ratio [OR] = 7.9, 95% CI: 4.7-13.2), and low income (OR = 3.1, 95% CI: 1.7-5.7). The use of an intrauterine device (IUD) ever (OR = 3.0, 95% CI: 1.4-6.1) and currently (OR = 4.1, 95% CI: 1.1-14.6), and ≥3 vaginal deliveries (OR = 5.2, 95% CI : 2.4-11.1) were associated with CIN II/III. History of infertility was also associated with CIN II/III (OR = 2.1, 95% CI : 1.0-4.2). Conclusions. The data suggest that history of infertility, IUD use and vaginal deliveries were associated with CIN among American Indian women.

KW - Cervix dysplasia

KW - Cross cultural comparison

KW - Indians North American

UR - http://www.scopus.com/inward/record.url?scp=0034533121&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034533121&partnerID=8YFLogxK

M3 - Article

C2 - 11101538

AN - SCOPUS:0034533121

VL - 29

SP - 983

EP - 998

JO - International Journal of Epidemiology

JF - International Journal of Epidemiology

SN - 0300-5771

IS - 6

ER -