Continuous oral contraceptives

Are bleeding patterns dependent on the hormones given?

Alison Edelman, Stephanie L. Koontz, Mark D. Nichols, Jeffrey Jensen

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

OBJECTIVE: To estimate whether progestin type or estrogen dose influences bleeding patterns, adverse effects, or satisfaction with combined oral contraceptives dosed continuously. METHODS: This was a randomized, double blind, 4-arm active treatment study. Subjects received either 100 μg levonorgestrel/20 μg ethinyl estradiol (E2) (20LNG group), 100 μ levonorgestrel/30 μg ethinyl E2 (30LNG group), 1,000 μg norethindrone acetate/20 μg ethinyl E2 (20NETA group), or 1,000 μg norethindrone acetate/30 μg ethinyl E2 (30NETA group) for 180 days. Subjects logged bleeding events and adverse effects on a daily menstrual calendar. An exit survey measured satisfaction with bleeding patterns. RESULTS: One hundred thirty-nine women were enrolled. Patients in the 20NETA and 30NETA arms had significantly more days of amenorrhea than the 30LNG arm in the second 90 days (P <.008). The 30LNG group reported more spotting days than the 20NETA group over the entire study period (P <.008) and the 30NETA group for the second 90 days (P <.008). Only a small number of bleeding days were reported with no differences between groups. No differences in adverse effects between groups were found. Women in the 30LNG arm reported lower levels of satisfaction with their bleeding patterns than the other groups (30LNG compared with 20NETA, P = .01; 30LNG compared with 30NETA, P = .001). CONCLUSION: The addition of 10 μg of ethinyl E2 to a 20 μg ethinyl E2 pill containing levonorgestrel or norethindrone acetate did not improve bleeding patterns. During continuous dosing, the use of oral contraceptives containing 1,000 μg norethindrone acetate resulted in more days of amenorrhea and fewer days of spotting than preparations containing 100 μg levonorgestrel.

Original languageEnglish (US)
Pages (from-to)657-665
Number of pages9
JournalObstetrics and Gynecology
Volume107
Issue number3
DOIs
StatePublished - Mar 2006

Fingerprint

Oral Contraceptives
Levonorgestrel
Hormones
Hemorrhage
Metrorrhagia
Amenorrhea
Contraceptives, Oral, Combined
Ethinyl Estradiol
Progestins
Estrogens
norethindrone acetate

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Continuous oral contraceptives : Are bleeding patterns dependent on the hormones given? / Edelman, Alison; Koontz, Stephanie L.; Nichols, Mark D.; Jensen, Jeffrey.

In: Obstetrics and Gynecology, Vol. 107, No. 3, 03.2006, p. 657-665.

Research output: Contribution to journalArticle

@article{e6475d3de1094cab92465ec1e1a55dd2,
title = "Continuous oral contraceptives: Are bleeding patterns dependent on the hormones given?",
abstract = "OBJECTIVE: To estimate whether progestin type or estrogen dose influences bleeding patterns, adverse effects, or satisfaction with combined oral contraceptives dosed continuously. METHODS: This was a randomized, double blind, 4-arm active treatment study. Subjects received either 100 μg levonorgestrel/20 μg ethinyl estradiol (E2) (20LNG group), 100 μ levonorgestrel/30 μg ethinyl E2 (30LNG group), 1,000 μg norethindrone acetate/20 μg ethinyl E2 (20NETA group), or 1,000 μg norethindrone acetate/30 μg ethinyl E2 (30NETA group) for 180 days. Subjects logged bleeding events and adverse effects on a daily menstrual calendar. An exit survey measured satisfaction with bleeding patterns. RESULTS: One hundred thirty-nine women were enrolled. Patients in the 20NETA and 30NETA arms had significantly more days of amenorrhea than the 30LNG arm in the second 90 days (P <.008). The 30LNG group reported more spotting days than the 20NETA group over the entire study period (P <.008) and the 30NETA group for the second 90 days (P <.008). Only a small number of bleeding days were reported with no differences between groups. No differences in adverse effects between groups were found. Women in the 30LNG arm reported lower levels of satisfaction with their bleeding patterns than the other groups (30LNG compared with 20NETA, P = .01; 30LNG compared with 30NETA, P = .001). CONCLUSION: The addition of 10 μg of ethinyl E2 to a 20 μg ethinyl E2 pill containing levonorgestrel or norethindrone acetate did not improve bleeding patterns. During continuous dosing, the use of oral contraceptives containing 1,000 μg norethindrone acetate resulted in more days of amenorrhea and fewer days of spotting than preparations containing 100 μg levonorgestrel.",
author = "Alison Edelman and Koontz, {Stephanie L.} and Nichols, {Mark D.} and Jeffrey Jensen",
year = "2006",
month = "3",
doi = "10.1097/01.AOG.0000199950.64545.16",
language = "English (US)",
volume = "107",
pages = "657--665",
journal = "Obstetrics and Gynecology",
issn = "0029-7844",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Continuous oral contraceptives

T2 - Are bleeding patterns dependent on the hormones given?

AU - Edelman, Alison

AU - Koontz, Stephanie L.

AU - Nichols, Mark D.

AU - Jensen, Jeffrey

PY - 2006/3

Y1 - 2006/3

N2 - OBJECTIVE: To estimate whether progestin type or estrogen dose influences bleeding patterns, adverse effects, or satisfaction with combined oral contraceptives dosed continuously. METHODS: This was a randomized, double blind, 4-arm active treatment study. Subjects received either 100 μg levonorgestrel/20 μg ethinyl estradiol (E2) (20LNG group), 100 μ levonorgestrel/30 μg ethinyl E2 (30LNG group), 1,000 μg norethindrone acetate/20 μg ethinyl E2 (20NETA group), or 1,000 μg norethindrone acetate/30 μg ethinyl E2 (30NETA group) for 180 days. Subjects logged bleeding events and adverse effects on a daily menstrual calendar. An exit survey measured satisfaction with bleeding patterns. RESULTS: One hundred thirty-nine women were enrolled. Patients in the 20NETA and 30NETA arms had significantly more days of amenorrhea than the 30LNG arm in the second 90 days (P <.008). The 30LNG group reported more spotting days than the 20NETA group over the entire study period (P <.008) and the 30NETA group for the second 90 days (P <.008). Only a small number of bleeding days were reported with no differences between groups. No differences in adverse effects between groups were found. Women in the 30LNG arm reported lower levels of satisfaction with their bleeding patterns than the other groups (30LNG compared with 20NETA, P = .01; 30LNG compared with 30NETA, P = .001). CONCLUSION: The addition of 10 μg of ethinyl E2 to a 20 μg ethinyl E2 pill containing levonorgestrel or norethindrone acetate did not improve bleeding patterns. During continuous dosing, the use of oral contraceptives containing 1,000 μg norethindrone acetate resulted in more days of amenorrhea and fewer days of spotting than preparations containing 100 μg levonorgestrel.

AB - OBJECTIVE: To estimate whether progestin type or estrogen dose influences bleeding patterns, adverse effects, or satisfaction with combined oral contraceptives dosed continuously. METHODS: This was a randomized, double blind, 4-arm active treatment study. Subjects received either 100 μg levonorgestrel/20 μg ethinyl estradiol (E2) (20LNG group), 100 μ levonorgestrel/30 μg ethinyl E2 (30LNG group), 1,000 μg norethindrone acetate/20 μg ethinyl E2 (20NETA group), or 1,000 μg norethindrone acetate/30 μg ethinyl E2 (30NETA group) for 180 days. Subjects logged bleeding events and adverse effects on a daily menstrual calendar. An exit survey measured satisfaction with bleeding patterns. RESULTS: One hundred thirty-nine women were enrolled. Patients in the 20NETA and 30NETA arms had significantly more days of amenorrhea than the 30LNG arm in the second 90 days (P <.008). The 30LNG group reported more spotting days than the 20NETA group over the entire study period (P <.008) and the 30NETA group for the second 90 days (P <.008). Only a small number of bleeding days were reported with no differences between groups. No differences in adverse effects between groups were found. Women in the 30LNG arm reported lower levels of satisfaction with their bleeding patterns than the other groups (30LNG compared with 20NETA, P = .01; 30LNG compared with 30NETA, P = .001). CONCLUSION: The addition of 10 μg of ethinyl E2 to a 20 μg ethinyl E2 pill containing levonorgestrel or norethindrone acetate did not improve bleeding patterns. During continuous dosing, the use of oral contraceptives containing 1,000 μg norethindrone acetate resulted in more days of amenorrhea and fewer days of spotting than preparations containing 100 μg levonorgestrel.

UR - http://www.scopus.com/inward/record.url?scp=33646772175&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33646772175&partnerID=8YFLogxK

U2 - 10.1097/01.AOG.0000199950.64545.16

DO - 10.1097/01.AOG.0000199950.64545.16

M3 - Article

VL - 107

SP - 657

EP - 665

JO - Obstetrics and Gynecology

JF - Obstetrics and Gynecology

SN - 0029-7844

IS - 3

ER -