@article{b68c1da2cf324dfebeaa3e5628d56c91,
title = "Continuous high-grade mycobacterium avium-intracellulare bacteremia in patients with the acquired immune deficiency syndrome",
abstract = "Serial quantitative blood cultures were performed before and during treatment in four patients with the acquired immune deficiency syndrome (AIDS) and Mycobacterium avium-intracellulare bacteremia. Initial colony counts were 350 to 28,000 cfu/ml, the counts declined substantially with treatment in two patients, and they declined modestly with treatment but rose when it was stopped in the other two. In one patient who was studied In detail, most of the circulating organisms were within the leukocytes, colony counts in blood subjected to lytic agents were 1.9- to 5.2-fold higher than In unlysed blood, and there were 105 to 106 times more organisms per gram in several tissue specimens obtained at autopsy than per milliliter of blood. It is concluded that continuous high-grade bacteremia is common in patients with AIDS and severe M. avium-intracellulare infections and that serial quantitative blood cultures provide a potential means for studying treatment in these patients.",
author = "Brian Wong and Edwards, {Fitzroy F.} and Kiehn, {Timothy E.} and Estella Whimbey and Harrison Donnelly and Bernard, {Edward M.} and Gold, {Jonathan W.M.} and Donald Armstrong",
note = "Funding Information: From the Infectious Disease Service and Diagnostic Microbiology Laboratory, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York. This work was presented in abstract form at the Eastern Section American Federation for Clinical Research Meeting, Boston, Massachusetts, October 1983. Dr. Wong was supported in part by American Cancer Society Junior Faculty Clinical Fellowship 0958 from the American Cancer Society, New York, New York. Requests for reprints should be addressed to Dr. Donakl Armstrong, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021. Manuscript accepted Jun8 25, 1984. l Crsrent address: Division of Infectious Diseases, Department of Internal Medicine, University Cincinnati College of Medicine, 231 Bethesda Avenue, Cincinnati, Ohio 45287.",
year = "1985",
month = jan,
doi = "10.1016/0002-9343(85)90458-9",
language = "English (US)",
volume = "78",
pages = "35--40",
journal = "American Journal of Medicine",
issn = "0002-9343",
publisher = "Elsevier Inc.",
number = "1",
}