Contemporary management of renal tumors with venous tumor thrombus

Frédéric Pouliot, Brian Shuch, Jeffrey C. Larochelle, Allan Pantuck, Arie S. Belldegrun

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Purpose: Renal cell carcinoma with intravenous tumor thrombus remains one of the most intriguing and challenging topics in urological oncology. With better understanding of the biology of intravascular tumor invasion and improvements in overall survival, the surgical and medical treatment of these patients is being completely redefined. Materials and Methods: We performed a MEDLINE® search for relevant articles on renal cell carcinoma with intravenous tumor thrombus. Results: We describe the staging systems, prognostic factors and surgical techniques involved in the management of renal cell carcinoma with intravenous tumor thrombus. We also review long-term survival of local, advanced and metastatic renal cell carcinoma with tumor thrombus invasion. Finally, we propose a clinical algorithm for the treatment of patients with renal cell carcinoma invading the venous system. Conclusions: Management of a kidney cancer tumor invading the venous system should now consider the primary biology and natural behavior of a given tumor in that specific patient rather than only focusing on the level and extent of venous invasion. Treatment must be individualized for every patient based on performance status, tumor biology and risk of surgery.

Original languageEnglish (US)
Pages (from-to)833-841
Number of pages9
JournalJournal of Urology
Volume184
Issue number3
DOIs
StatePublished - Sep 2010
Externally publishedYes

Fingerprint

Thrombosis
Kidney
Renal Cell Carcinoma
Neoplasms
Survival
Kidney Neoplasms
MEDLINE
Therapeutics

Keywords

  • carcinoma, renal cell
  • kidney neoplasms
  • neoplasm invasiveness

ASJC Scopus subject areas

  • Urology
  • Medicine(all)

Cite this

Pouliot, F., Shuch, B., Larochelle, J. C., Pantuck, A., & Belldegrun, A. S. (2010). Contemporary management of renal tumors with venous tumor thrombus. Journal of Urology, 184(3), 833-841. https://doi.org/10.1016/j.juro.2010.04.071

Contemporary management of renal tumors with venous tumor thrombus. / Pouliot, Frédéric; Shuch, Brian; Larochelle, Jeffrey C.; Pantuck, Allan; Belldegrun, Arie S.

In: Journal of Urology, Vol. 184, No. 3, 09.2010, p. 833-841.

Research output: Contribution to journalArticle

Pouliot, F, Shuch, B, Larochelle, JC, Pantuck, A & Belldegrun, AS 2010, 'Contemporary management of renal tumors with venous tumor thrombus', Journal of Urology, vol. 184, no. 3, pp. 833-841. https://doi.org/10.1016/j.juro.2010.04.071
Pouliot F, Shuch B, Larochelle JC, Pantuck A, Belldegrun AS. Contemporary management of renal tumors with venous tumor thrombus. Journal of Urology. 2010 Sep;184(3):833-841. https://doi.org/10.1016/j.juro.2010.04.071
Pouliot, Frédéric ; Shuch, Brian ; Larochelle, Jeffrey C. ; Pantuck, Allan ; Belldegrun, Arie S. / Contemporary management of renal tumors with venous tumor thrombus. In: Journal of Urology. 2010 ; Vol. 184, No. 3. pp. 833-841.
@article{454dfb008ecf4a5594b0325f095aa3eb,
title = "Contemporary management of renal tumors with venous tumor thrombus",
abstract = "Purpose: Renal cell carcinoma with intravenous tumor thrombus remains one of the most intriguing and challenging topics in urological oncology. With better understanding of the biology of intravascular tumor invasion and improvements in overall survival, the surgical and medical treatment of these patients is being completely redefined. Materials and Methods: We performed a MEDLINE{\circledR} search for relevant articles on renal cell carcinoma with intravenous tumor thrombus. Results: We describe the staging systems, prognostic factors and surgical techniques involved in the management of renal cell carcinoma with intravenous tumor thrombus. We also review long-term survival of local, advanced and metastatic renal cell carcinoma with tumor thrombus invasion. Finally, we propose a clinical algorithm for the treatment of patients with renal cell carcinoma invading the venous system. Conclusions: Management of a kidney cancer tumor invading the venous system should now consider the primary biology and natural behavior of a given tumor in that specific patient rather than only focusing on the level and extent of venous invasion. Treatment must be individualized for every patient based on performance status, tumor biology and risk of surgery.",
keywords = "carcinoma, renal cell, kidney neoplasms, neoplasm invasiveness",
author = "Fr{\'e}d{\'e}ric Pouliot and Brian Shuch and Larochelle, {Jeffrey C.} and Allan Pantuck and Belldegrun, {Arie S.}",
year = "2010",
month = "9",
doi = "10.1016/j.juro.2010.04.071",
language = "English (US)",
volume = "184",
pages = "833--841",
journal = "Journal of Urology",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Contemporary management of renal tumors with venous tumor thrombus

AU - Pouliot, Frédéric

AU - Shuch, Brian

AU - Larochelle, Jeffrey C.

AU - Pantuck, Allan

AU - Belldegrun, Arie S.

PY - 2010/9

Y1 - 2010/9

N2 - Purpose: Renal cell carcinoma with intravenous tumor thrombus remains one of the most intriguing and challenging topics in urological oncology. With better understanding of the biology of intravascular tumor invasion and improvements in overall survival, the surgical and medical treatment of these patients is being completely redefined. Materials and Methods: We performed a MEDLINE® search for relevant articles on renal cell carcinoma with intravenous tumor thrombus. Results: We describe the staging systems, prognostic factors and surgical techniques involved in the management of renal cell carcinoma with intravenous tumor thrombus. We also review long-term survival of local, advanced and metastatic renal cell carcinoma with tumor thrombus invasion. Finally, we propose a clinical algorithm for the treatment of patients with renal cell carcinoma invading the venous system. Conclusions: Management of a kidney cancer tumor invading the venous system should now consider the primary biology and natural behavior of a given tumor in that specific patient rather than only focusing on the level and extent of venous invasion. Treatment must be individualized for every patient based on performance status, tumor biology and risk of surgery.

AB - Purpose: Renal cell carcinoma with intravenous tumor thrombus remains one of the most intriguing and challenging topics in urological oncology. With better understanding of the biology of intravascular tumor invasion and improvements in overall survival, the surgical and medical treatment of these patients is being completely redefined. Materials and Methods: We performed a MEDLINE® search for relevant articles on renal cell carcinoma with intravenous tumor thrombus. Results: We describe the staging systems, prognostic factors and surgical techniques involved in the management of renal cell carcinoma with intravenous tumor thrombus. We also review long-term survival of local, advanced and metastatic renal cell carcinoma with tumor thrombus invasion. Finally, we propose a clinical algorithm for the treatment of patients with renal cell carcinoma invading the venous system. Conclusions: Management of a kidney cancer tumor invading the venous system should now consider the primary biology and natural behavior of a given tumor in that specific patient rather than only focusing on the level and extent of venous invasion. Treatment must be individualized for every patient based on performance status, tumor biology and risk of surgery.

KW - carcinoma, renal cell

KW - kidney neoplasms

KW - neoplasm invasiveness

UR - http://www.scopus.com/inward/record.url?scp=77956633781&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77956633781&partnerID=8YFLogxK

U2 - 10.1016/j.juro.2010.04.071

DO - 10.1016/j.juro.2010.04.071

M3 - Article

C2 - 20643450

AN - SCOPUS:77956633781

VL - 184

SP - 833

EP - 841

JO - Journal of Urology

JF - Journal of Urology

SN - 0022-5347

IS - 3

ER -