Contact system sends defensins to the rescue

Laura D. Healy, Owen McCarty

Research output: Contribution to journalReview article

Abstract

In this issue of Blood, Abu-Fanne et al identify a link between activation of the contact system of coagulation involving factor XIIa (FXIIa) and kallikrein, promoting neutrophils to release the antimicrobial peptide a-defensin-1, which enhances fibrin polymerization kinetics, alters fibrin morphology, and inhibits fibrinolysis. These reactions may serve as an extension or consequence of innate immunity and are shown to affect in vivo murine thrombosis.

Original languageEnglish (US)
Pages (from-to)385-386
Number of pages2
JournalBlood
Volume133
Issue number5
DOIs
StatePublished - Jan 31 2019

Fingerprint

Defensins
Fibrin
Factor XIIa
Kallikreins
Fibrinolysis
Coagulation
Innate Immunity
Polymerization
Neutrophils
Thrombosis
Blood
Chemical activation
Peptides
Kinetics

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

Cite this

Contact system sends defensins to the rescue. / Healy, Laura D.; McCarty, Owen.

In: Blood, Vol. 133, No. 5, 31.01.2019, p. 385-386.

Research output: Contribution to journalReview article

Healy, Laura D. ; McCarty, Owen. / Contact system sends defensins to the rescue. In: Blood. 2019 ; Vol. 133, No. 5. pp. 385-386.
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