Constitutive absence and interferon-γ-induced expression of adhesion molecules in basal cell carcinoma

R. S. Taylor, C. E M Griffiths, M. D. Brown, Neil Swanson, B. J. Nickoloff

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Adhesion of lymphocytes to target cells via certain cell surface molecules is important in cytotoxic T lymphocyte-mediated immune reactions. The binding of lymphocyte function-associated (LFA) antigens 1 and 2, with their respective ligands, intercullular adhesion molecule-1 (ICAM-1) and LFA-3, which are expressed on the surface of nonlymphoid cells, has been shown to be critical for lymphocyte adhesion. To determine whether basal cell carcinomas (BCCs) can escape immunodetection as a result of the inability of cytotoxic T lymphocytes to bind tumor cells, the expression of adhesion molecules on numerous BCCs, before and after exposure to interferon-γ (IFN-Γ), was examined. Ninety-three percent of 30 freshly excised invasive BCCs did not express ICAM-1 and 73% of 11 BCCs did not express LFA-3. However, the normal-appearing basal keratinocytes in epidermis overlyings nests of BCC, did express ICAM-1, particularly when a marked LFA-1+ and LFA-2+ dermal lymphocytic infiltrate was present. After BCC tissue was incubated in vitro with IFN-γ the expression of ICAM-1 was induced on 85% of tumors studied. Thus tumor cells did not possess an absolute inability to express adhesion molecules; rather the constitutive absence of such molecules may be due to insufficient in vivo cytokine levels necessary to induce expression or a barrier preventing cytokines from reaching and interacting with tumor cells. We conclude that the absence of ICAM-1 and LFA-3 adhesion molecules is a mechanism by which BCCs can avoid immunosurveillance.

Original languageEnglish (US)
Pages (from-to)721-726
Number of pages6
JournalJournal of the American Academy of Dermatology
Volume22
Issue number5 I
StatePublished - 1990
Externally publishedYes

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Basal Cell Carcinoma
Interferons
Lymphocytes
Cytotoxic T-Lymphocytes
Neoplasms
Cytokines
Immunologic Monitoring
Lymphocyte Function-Associated Antigen-1
Cell Adhesion Molecules
Keratinocytes
Epidermis
Ligands
Skin

ASJC Scopus subject areas

  • Dermatology

Cite this

Taylor, R. S., Griffiths, C. E. M., Brown, M. D., Swanson, N., & Nickoloff, B. J. (1990). Constitutive absence and interferon-γ-induced expression of adhesion molecules in basal cell carcinoma. Journal of the American Academy of Dermatology, 22(5 I), 721-726.

Constitutive absence and interferon-γ-induced expression of adhesion molecules in basal cell carcinoma. / Taylor, R. S.; Griffiths, C. E M; Brown, M. D.; Swanson, Neil; Nickoloff, B. J.

In: Journal of the American Academy of Dermatology, Vol. 22, No. 5 I, 1990, p. 721-726.

Research output: Contribution to journalArticle

Taylor, RS, Griffiths, CEM, Brown, MD, Swanson, N & Nickoloff, BJ 1990, 'Constitutive absence and interferon-γ-induced expression of adhesion molecules in basal cell carcinoma', Journal of the American Academy of Dermatology, vol. 22, no. 5 I, pp. 721-726.
Taylor, R. S. ; Griffiths, C. E M ; Brown, M. D. ; Swanson, Neil ; Nickoloff, B. J. / Constitutive absence and interferon-γ-induced expression of adhesion molecules in basal cell carcinoma. In: Journal of the American Academy of Dermatology. 1990 ; Vol. 22, No. 5 I. pp. 721-726.
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