Constitutive absence and interferon-γ-induced expression of adhesion molecules in basal cell carcinoma

R. S. Taylor, C. E M Griffiths, M. D. Brown, Neil Swanson, B. J. Nickoloff

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Adhesion of lymphocytes to target cells via certain cell surface molecules is important in cytotoxic T lymphocyte-mediated immune reactions. The binding of lymphocyte function-associated (LFA) antigens 1 and 2, with their respective ligands, intercullular adhesion molecule-1 (ICAM-1) and LFA-3, which are expressed on the surface of nonlymphoid cells, has been shown to be critical for lymphocyte adhesion. To determine whether basal cell carcinomas (BCCs) can escape immunodetection as a result of the inability of cytotoxic T lymphocytes to bind tumor cells, the expression of adhesion molecules on numerous BCCs, before and after exposure to interferon-γ (IFN-Γ), was examined. Ninety-three percent of 30 freshly excised invasive BCCs did not express ICAM-1 and 73% of 11 BCCs did not express LFA-3. However, the normal-appearing basal keratinocytes in epidermis overlyings nests of BCC, did express ICAM-1, particularly when a marked LFA-1+ and LFA-2+ dermal lymphocytic infiltrate was present. After BCC tissue was incubated in vitro with IFN-γ the expression of ICAM-1 was induced on 85% of tumors studied. Thus tumor cells did not possess an absolute inability to express adhesion molecules; rather the constitutive absence of such molecules may be due to insufficient in vivo cytokine levels necessary to induce expression or a barrier preventing cytokines from reaching and interacting with tumor cells. We conclude that the absence of ICAM-1 and LFA-3 adhesion molecules is a mechanism by which BCCs can avoid immunosurveillance.

Original languageEnglish (US)
Pages (from-to)721-726
Number of pages6
JournalJournal of the American Academy of Dermatology
Volume22
Issue number5 I
Publication statusPublished - 1990
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • Dermatology

Cite this

Taylor, R. S., Griffiths, C. E. M., Brown, M. D., Swanson, N., & Nickoloff, B. J. (1990). Constitutive absence and interferon-γ-induced expression of adhesion molecules in basal cell carcinoma. Journal of the American Academy of Dermatology, 22(5 I), 721-726.