Consensus Recommendations for the Diagnosis of Vitreoretinal Lymphoma

the Study Group for Vitreoretinal Lymphoma Diagnostics

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Purpose: To provide recommendations for diagnosis of vitreoretinal lymphoma (VRL). Methods: Literature was reviewed for reports supporting the diagnosis of VRL. A questionnaire (Delphi 1 round) was distributed to 28 participants. In the second round (Delphi 2), items of the questionnaire not reaching consensus (75% agreement) were discussed to finalize the recommendations. Results: Presenting symptoms include floaters and painless loss of vision, vitreous cells organized into sheets or clumps. Retinal lesions are usually multifocal creamy/white in the outer retina. Other findings include retinal lesions with “leopard-skin” appearance and retinal pigment epithelium atrophy. Severe vitreous infiltration without macular edema is the most likely presentation. Diagnostic vitrectomy should be performed. Systemic corticosteroid should be discontinued at least 2 weeks before surgery. An interleukin (IL)-10:IL-6 ratio > 1, positive mutation for the myeloid differentiation primary response 88 gene and monoclonality are indicators of VRL. Multi-modal imaging (optical coherence tomography, fundus autofluorescence) are recommended. Conclusions: A consensus meeting allowed the establishment of recommendations important for the diagnosis of VRL.

Original languageEnglish (US)
Pages (from-to)507-520
Number of pages14
JournalOcular Immunology and Inflammation
Volume29
Issue number3
DOIs
StatePublished - 2021

Keywords

  • consensus recommendations
  • diagnosis
  • Vitreoretinal lymphoma

ASJC Scopus subject areas

  • Immunology and Allergy
  • Ophthalmology

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