Consensus on diagnosis and management of Cushing's disease: a guideline update

Maria Fleseriu; Richard Auchus; Irina Bancos; Anat Ben-Shlomo; Jerome Bertherat; Nienke R. Biermasz; Cesar L. Boguszewski; Marcello D. Bronstein; Michael Buchfelder; John D. Carmichael; Felipe F. Casanueva; Frederic Castinetti; Philippe Chanson; James Findling; Mônica Gadelha; Eliza B. Geer; Andrea Giustina; Ashley Grossman; Mark Gurnell; Ken Ho; Adriana G. Ioachimescu; Ursula B. Kaiser; Niki Karavitaki; Laurence Katznelson; Daniel F. Kelly; André Lacroix; Ann McCormack; Shlomo Melmed; Mark Molitch; Pietro Mortini; John Newell-Price; Lynnette Nieman; Alberto M. Pereira; Stephan Petersenn; Rosario Pivonello; Hershel Raff; Martin Reincke; Roberto Salvatori; Carla Scaroni; Ilan Shimon; Constantine A. Stratakis; Brooke Swearingen; Antoine Tabarin; Yutaka Takahashi; Marily Theodoropoulou; Stylianos Tsagarakis; Elena Valassi; Elena V. Varlamov; Greisa Vila; John Wass; Susan M. Webb; Maria C. Zatelli; Beverly M.K. Biller

doi:10.1016/S2213-8587(21)00235-7

Consensus on diagnosis and management of Cushing's disease: a guideline update

Maria Fleseriu, Richard Auchus, Irina Bancos, Anat Ben-Shlomo, Jerome Bertherat, Nienke R. Biermasz, Cesar L. Boguszewski, Marcello D. Bronstein, Michael Buchfelder, John D. Carmichael, Felipe F. Casanueva, Frederic Castinetti, Philippe Chanson, James Findling, Mônica Gadelha, Eliza B. Geer, Andrea Giustina, Ashley Grossman, Mark Gurnell, Ken HoAdriana G. Ioachimescu, Ursula B. Kaiser, Niki Karavitaki, Laurence Katznelson, Daniel F. Kelly, André Lacroix, Ann McCormack, Shlomo Melmed, Mark Molitch, Pietro Mortini, John Newell-Price, Lynnette Nieman, Alberto M. Pereira, Stephan Petersenn, Rosario Pivonello, Hershel Raff, Martin Reincke, Roberto Salvatori, Carla Scaroni, Ilan Shimon, Constantine A. Stratakis, Brooke Swearingen, Antoine Tabarin, Yutaka Takahashi, Marily Theodoropoulou, Stylianos Tsagarakis, Elena Valassi, Elena V. Varlamov, Greisa Vila, John Wass, Susan M. Webb, Maria C. Zatelli, Beverly M.K. Biller

Neurological Surgery

Research output: Contribution to journal › Review article › peer-review

304 Scopus citations

Abstract

Cushing's disease requires accurate diagnosis, careful treatment selection, and long-term management to optimise patient outcomes. The Pituitary Society convened a consensus workshop comprising more than 50 academic researchers and clinical experts to discuss the application of recent evidence to clinical practice. In advance of the virtual meeting, data from 2015 to present about screening and diagnosis; surgery, medical, and radiation therapy; and disease-related and treatment-related complications of Cushing's disease summarised in recorded lectures were reviewed by all participants. During the meeting, concise summaries of the recorded lectures were presented, followed by small group breakout discussions. Consensus opinions from each group were collated into a draft document, which was reviewed and approved by all participants. Recommendations regarding use of laboratory tests, imaging, and treatment options are presented, along with algorithms for diagnosis of Cushing's syndrome and management of Cushing's disease. Topics considered most important to address in future research are also identified.

Original language	English (US)
Pages (from-to)	847-875
Number of pages	29
Journal	The Lancet Diabetes and Endocrinology
Volume	9
Issue number	12
DOIs	https://doi.org/10.1016/S2213-8587(21)00235-7
State	Published - Dec 2021

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Endocrinology

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Fleseriu, M., Auchus, R., Bancos, I., Ben-Shlomo, A., Bertherat, J., Biermasz, N. R., Boguszewski, C. L., Bronstein, M. D., Buchfelder, M., Carmichael, J. D., Casanueva, F. F., Castinetti, F., Chanson, P., Findling, J., Gadelha, M., Geer, E. B., Giustina, A., Grossman, A., Gurnell, M., ... Biller, B. M. K. (2021). Consensus on diagnosis and management of Cushing's disease: a guideline update. The Lancet Diabetes and Endocrinology, 9(12), 847-875. https://doi.org/10.1016/S2213-8587(21)00235-7

Fleseriu, M, Auchus, R, Bancos, I, Ben-Shlomo, A, Bertherat, J, Biermasz, NR, Boguszewski, CL, Bronstein, MD, Buchfelder, M, Carmichael, JD, Casanueva, FF, Castinetti, F, Chanson, P, Findling, J, Gadelha, M, Geer, EB, Giustina, A, Grossman, A, Gurnell, M, Ho, K, Ioachimescu, AG, Kaiser, UB, Karavitaki, N, Katznelson, L, Kelly, DF, Lacroix, A, McCormack, A, Melmed, S, Molitch, M, Mortini, P, Newell-Price, J, Nieman, L, Pereira, AM, Petersenn, S, Pivonello, R, Raff, H, Reincke, M, Salvatori, R, Scaroni, C, Shimon, I, Stratakis, CA, Swearingen, B, Tabarin, A, Takahashi, Y, Theodoropoulou, M, Tsagarakis, S, Valassi, E, Varlamov, EV, Vila, G, Wass, J, Webb, SM, Zatelli, MC & Biller, BMK 2021, 'Consensus on diagnosis and management of Cushing's disease: a guideline update', The Lancet Diabetes and Endocrinology, vol. 9, no. 12, pp. 847-875. https://doi.org/10.1016/S2213-8587(21)00235-7

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title = "Consensus on diagnosis and management of Cushing's disease: a guideline update",

abstract = "Cushing's disease requires accurate diagnosis, careful treatment selection, and long-term management to optimise patient outcomes. The Pituitary Society convened a consensus workshop comprising more than 50 academic researchers and clinical experts to discuss the application of recent evidence to clinical practice. In advance of the virtual meeting, data from 2015 to present about screening and diagnosis; surgery, medical, and radiation therapy; and disease-related and treatment-related complications of Cushing's disease summarised in recorded lectures were reviewed by all participants. During the meeting, concise summaries of the recorded lectures were presented, followed by small group breakout discussions. Consensus opinions from each group were collated into a draft document, which was reviewed and approved by all participants. Recommendations regarding use of laboratory tests, imaging, and treatment options are presented, along with algorithms for diagnosis of Cushing's syndrome and management of Cushing's disease. Topics considered most important to address in future research are also identified.",

author = "Maria Fleseriu and Richard Auchus and Irina Bancos and Anat Ben-Shlomo and Jerome Bertherat and Biermasz, {Nienke R.} and Boguszewski, {Cesar L.} and Bronstein, {Marcello D.} and Michael Buchfelder and Carmichael, {John D.} and Casanueva, {Felipe F.} and Frederic Castinetti and Philippe Chanson and James Findling and M{\^o}nica Gadelha and Geer, {Eliza B.} and Andrea Giustina and Ashley Grossman and Mark Gurnell and Ken Ho and Ioachimescu, {Adriana G.} and Kaiser, {Ursula B.} and Niki Karavitaki and Laurence Katznelson and Kelly, {Daniel F.} and Andr{\'e} Lacroix and Ann McCormack and Shlomo Melmed and Mark Molitch and Pietro Mortini and John Newell-Price and Lynnette Nieman and Pereira, {Alberto M.} and Stephan Petersenn and Rosario Pivonello and Hershel Raff and Martin Reincke and Roberto Salvatori and Carla Scaroni and Ilan Shimon and Stratakis, {Constantine A.} and Brooke Swearingen and Antoine Tabarin and Yutaka Takahashi and Marily Theodoropoulou and Stylianos Tsagarakis and Elena Valassi and Varlamov, {Elena V.} and Greisa Vila and John Wass and Webb, {Susan M.} and Zatelli, {Maria C.} and Biller, {Beverly M.K.}",

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AU - Auchus, Richard

AU - Bancos, Irina

AU - Ben-Shlomo, Anat

AU - Bertherat, Jerome

AU - Biermasz, Nienke R.

AU - Boguszewski, Cesar L.

AU - Bronstein, Marcello D.

AU - Buchfelder, Michael

AU - Carmichael, John D.

AU - Casanueva, Felipe F.

AU - Castinetti, Frederic

AU - Chanson, Philippe

AU - Findling, James

AU - Gadelha, Mônica

AU - Geer, Eliza B.

AU - Giustina, Andrea

AU - Grossman, Ashley

AU - Gurnell, Mark

AU - Ho, Ken

AU - Ioachimescu, Adriana G.

AU - Kaiser, Ursula B.

AU - Karavitaki, Niki

AU - Katznelson, Laurence

AU - Kelly, Daniel F.

AU - Lacroix, André

AU - McCormack, Ann

AU - Melmed, Shlomo

AU - Molitch, Mark

AU - Mortini, Pietro

AU - Newell-Price, John

AU - Nieman, Lynnette

AU - Pereira, Alberto M.

AU - Petersenn, Stephan

AU - Pivonello, Rosario

AU - Raff, Hershel

AU - Reincke, Martin

AU - Salvatori, Roberto

AU - Scaroni, Carla

AU - Shimon, Ilan

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AU - Tabarin, Antoine

AU - Takahashi, Yutaka

AU - Theodoropoulou, Marily

AU - Tsagarakis, Stylianos

AU - Valassi, Elena

AU - Varlamov, Elena V.

AU - Vila, Greisa

AU - Wass, John

AU - Webb, Susan M.

AU - Zatelli, Maria C.

AU - Biller, Beverly M.K.

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Consensus on diagnosis and management of Cushing's disease: a guideline update

Abstract

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