Connexin36 mediates spike synchrony in olfactory bulb glomeruli

Jason M. Christie, Christine Bark, Sheriar G. Hormuzdi, Ingo Helbig, Hannah Monyer, Gary Westbrook

Research output: Contribution to journalArticle

121 Citations (Scopus)

Abstract

Neuronal synchrony is important to network behavior in many brain regions. In the olfactory bulb, principal neurons (mitral cells) project apical dendrites to a common glomerulus where they receive a common input. Synchronized activity within a glomerulus depends on chemical transmission but mitral cells are also electrically coupled. We examined the role of connexin-mediated gap junctions in mitral cell coordinated activity. Electrical coupling as well as correlated spiking between mitral cells projecting to the same glomerulus was entirely absent in connexin36 (Cx36) knockout mice. Ultrastructural analysis of glomeruli confirmed that mitral-mitral cell gap junctions on distal apical dendrites contain Cx36. Coupled AMPA responses between mitral cell pairs were absent in the knockout, demonstrating that electrical coupling, not transmitter spillover, is responsible for synchronization. Our results indicate that Cx36-mediated gap junctions between mitral cells orchestrate rapid coordinated signaling via a novel form of electrochemical transmission.

Original languageEnglish (US)
Pages (from-to)761-772
Number of pages12
JournalNeuron
Volume46
Issue number5
DOIs
StatePublished - Jun 2 2005

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Olfactory Bulb
Gap Junctions
Dendrites
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Connexins
Intercellular Junctions
Knockout Mice
connexin 36
Neurons
Brain

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Christie, J. M., Bark, C., Hormuzdi, S. G., Helbig, I., Monyer, H., & Westbrook, G. (2005). Connexin36 mediates spike synchrony in olfactory bulb glomeruli. Neuron, 46(5), 761-772. https://doi.org/10.1016/j.neuron.2005.04.030

Connexin36 mediates spike synchrony in olfactory bulb glomeruli. / Christie, Jason M.; Bark, Christine; Hormuzdi, Sheriar G.; Helbig, Ingo; Monyer, Hannah; Westbrook, Gary.

In: Neuron, Vol. 46, No. 5, 02.06.2005, p. 761-772.

Research output: Contribution to journalArticle

Christie, JM, Bark, C, Hormuzdi, SG, Helbig, I, Monyer, H & Westbrook, G 2005, 'Connexin36 mediates spike synchrony in olfactory bulb glomeruli', Neuron, vol. 46, no. 5, pp. 761-772. https://doi.org/10.1016/j.neuron.2005.04.030
Christie JM, Bark C, Hormuzdi SG, Helbig I, Monyer H, Westbrook G. Connexin36 mediates spike synchrony in olfactory bulb glomeruli. Neuron. 2005 Jun 2;46(5):761-772. https://doi.org/10.1016/j.neuron.2005.04.030
Christie, Jason M. ; Bark, Christine ; Hormuzdi, Sheriar G. ; Helbig, Ingo ; Monyer, Hannah ; Westbrook, Gary. / Connexin36 mediates spike synchrony in olfactory bulb glomeruli. In: Neuron. 2005 ; Vol. 46, No. 5. pp. 761-772.
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