Congenital diaphragmatic hernia

Prenatal evaluation with MR lung volumetry - Preliminary experience

B. W. Paek, Fergus Coakley, Y. Lu, R. A. Filly, J. B. Lopoo, A. Qayyum, M. R. Harrison, C. T. Albanese

Research output: Contribution to journalArticle

137 Citations (Scopus)

Abstract

PURPOSE: To determine the interobserver variability of prenatal magnetic resonance (MR) lung volumetry and to assess the value of MR lung volumetric findings as predictors of outcome in fetuses with congenital diaphragmatic hernia. MATERIALS AND METHODS: Prenatal MR imaging was performed in 26 fetuses with unilateral congenital diaphragmatic hernia. Two independent observers performed planimetric measurement of lung volume. Relative lung volume was calculated as the observed total lung volume expressed as a percentage of the total lung volume predicted from fetal size. Relative lung volume was correlated with the ultrasonographic lung-head ratio in left-sided congenital diaphragmatic hernias evaluated before 27 weeks gestation (n = 21) and with pregnancy outcome in all cases of isolated left-sided congenital diaphragmatic hernia without prenatal intervention (n = 11). RESULTS: Observers demonstrated excellent agreement in total lung volume measurements at MR imaging, with an intraclass correlation coefficient of 0.95. Relative lung volume was positively correlated with lung-head ratio (r = 0.78, P <.001). By using rank order analysis in the pregnancy outcome group, relative lung volume was predictive of prognosis (P <.05) when adjusted for gestational age at delivery and birth weight. Three of four fetuses with a relative lung volume of less than 40% died. CONCLUSION: Interobserver agreement is high at MR lung volumetry, and its findings are predictive of outcome in fetuses with isolated left-sided congenital diaphragmatic hernia.

Original languageEnglish (US)
Pages (from-to)63-67
Number of pages5
JournalRadiology
Volume220
Issue number1
StatePublished - 2001
Externally publishedYes

Fingerprint

Magnetic Resonance Spectroscopy
Lung
Fetus
Lung Volume Measurements
Pregnancy Outcome
Congenital Diaphragmatic Hernias
Head
Magnetic Resonance Imaging
Observer Variation
Birth Weight
Gestational Age
Pregnancy

Keywords

  • Fetus, growth and development, 856.128, 856.8754
  • Fetus, MR, 60.121412, 60.12144, 856.121412, 856.12144
  • Fetus, respiratory system, 60.1496, 856.8758
  • Fetus, US, 856.12983, 856.12989
  • Hernia, diaphragmatic, 856.8754
  • Magnetic resonance (MR), volume measurement, 60.12144, 856.12144
  • Pregnancy, US, 856.12983, 856.1311

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Paek, B. W., Coakley, F., Lu, Y., Filly, R. A., Lopoo, J. B., Qayyum, A., ... Albanese, C. T. (2001). Congenital diaphragmatic hernia: Prenatal evaluation with MR lung volumetry - Preliminary experience. Radiology, 220(1), 63-67.

Congenital diaphragmatic hernia : Prenatal evaluation with MR lung volumetry - Preliminary experience. / Paek, B. W.; Coakley, Fergus; Lu, Y.; Filly, R. A.; Lopoo, J. B.; Qayyum, A.; Harrison, M. R.; Albanese, C. T.

In: Radiology, Vol. 220, No. 1, 2001, p. 63-67.

Research output: Contribution to journalArticle

Paek, BW, Coakley, F, Lu, Y, Filly, RA, Lopoo, JB, Qayyum, A, Harrison, MR & Albanese, CT 2001, 'Congenital diaphragmatic hernia: Prenatal evaluation with MR lung volumetry - Preliminary experience', Radiology, vol. 220, no. 1, pp. 63-67.
Paek, B. W. ; Coakley, Fergus ; Lu, Y. ; Filly, R. A. ; Lopoo, J. B. ; Qayyum, A. ; Harrison, M. R. ; Albanese, C. T. / Congenital diaphragmatic hernia : Prenatal evaluation with MR lung volumetry - Preliminary experience. In: Radiology. 2001 ; Vol. 220, No. 1. pp. 63-67.
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T1 - Congenital diaphragmatic hernia

T2 - Prenatal evaluation with MR lung volumetry - Preliminary experience

AU - Paek, B. W.

AU - Coakley, Fergus

AU - Lu, Y.

AU - Filly, R. A.

AU - Lopoo, J. B.

AU - Qayyum, A.

AU - Harrison, M. R.

AU - Albanese, C. T.

PY - 2001

Y1 - 2001

N2 - PURPOSE: To determine the interobserver variability of prenatal magnetic resonance (MR) lung volumetry and to assess the value of MR lung volumetric findings as predictors of outcome in fetuses with congenital diaphragmatic hernia. MATERIALS AND METHODS: Prenatal MR imaging was performed in 26 fetuses with unilateral congenital diaphragmatic hernia. Two independent observers performed planimetric measurement of lung volume. Relative lung volume was calculated as the observed total lung volume expressed as a percentage of the total lung volume predicted from fetal size. Relative lung volume was correlated with the ultrasonographic lung-head ratio in left-sided congenital diaphragmatic hernias evaluated before 27 weeks gestation (n = 21) and with pregnancy outcome in all cases of isolated left-sided congenital diaphragmatic hernia without prenatal intervention (n = 11). RESULTS: Observers demonstrated excellent agreement in total lung volume measurements at MR imaging, with an intraclass correlation coefficient of 0.95. Relative lung volume was positively correlated with lung-head ratio (r = 0.78, P <.001). By using rank order analysis in the pregnancy outcome group, relative lung volume was predictive of prognosis (P <.05) when adjusted for gestational age at delivery and birth weight. Three of four fetuses with a relative lung volume of less than 40% died. CONCLUSION: Interobserver agreement is high at MR lung volumetry, and its findings are predictive of outcome in fetuses with isolated left-sided congenital diaphragmatic hernia.

AB - PURPOSE: To determine the interobserver variability of prenatal magnetic resonance (MR) lung volumetry and to assess the value of MR lung volumetric findings as predictors of outcome in fetuses with congenital diaphragmatic hernia. MATERIALS AND METHODS: Prenatal MR imaging was performed in 26 fetuses with unilateral congenital diaphragmatic hernia. Two independent observers performed planimetric measurement of lung volume. Relative lung volume was calculated as the observed total lung volume expressed as a percentage of the total lung volume predicted from fetal size. Relative lung volume was correlated with the ultrasonographic lung-head ratio in left-sided congenital diaphragmatic hernias evaluated before 27 weeks gestation (n = 21) and with pregnancy outcome in all cases of isolated left-sided congenital diaphragmatic hernia without prenatal intervention (n = 11). RESULTS: Observers demonstrated excellent agreement in total lung volume measurements at MR imaging, with an intraclass correlation coefficient of 0.95. Relative lung volume was positively correlated with lung-head ratio (r = 0.78, P <.001). By using rank order analysis in the pregnancy outcome group, relative lung volume was predictive of prognosis (P <.05) when adjusted for gestational age at delivery and birth weight. Three of four fetuses with a relative lung volume of less than 40% died. CONCLUSION: Interobserver agreement is high at MR lung volumetry, and its findings are predictive of outcome in fetuses with isolated left-sided congenital diaphragmatic hernia.

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KW - Fetus, respiratory system, 60.1496, 856.8758

KW - Fetus, US, 856.12983, 856.12989

KW - Hernia, diaphragmatic, 856.8754

KW - Magnetic resonance (MR), volume measurement, 60.12144, 856.12144

KW - Pregnancy, US, 856.12983, 856.1311

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M3 - Article

VL - 220

SP - 63

EP - 67

JO - Radiology

JF - Radiology

SN - 0033-8419

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