Congenital and opportunistic infections

Ureaplasma species and Mycoplasma hominis

Ken B. Waites, Robert Schelonka, Li Xiao, Peta Grigsby, Miles J. Novy

    Research output: Contribution to journalArticle

    95 Citations (Scopus)

    Abstract

    There is strong evidence from clinical and experimental animal studies that ureaplasmas can invade the amnionic sac and induce an inflammatory response resulting in chorioamnionitis, preterm labor and neonatal lung injury. The ability of Ureaplasma spp. and Mycoplasma hominis to cause pneumonia, bacteremia, and meningitis in newborns can no longer be questioned. The association of Ureaplasma spp. with bronchopulmonary dysplasia has been supported by the majority of observational studies, but proof of causality is still lacking. The availability of molecular diagnostic technologies has enabled the designation of the two Ureaplasma biovars as individual species, but additional work must be done to establish whether there is differential pathogenicity between the Ureaplasma spp. or among their respective serovars. Future investigations to prevent prematurity should be directed toward identification and localization of specific micro-organisms combined with targeted antibiotic trials to determine whether such interventions can improve long-term infant outcomes.

    Original languageEnglish (US)
    Pages (from-to)190-199
    Number of pages10
    JournalSeminars in Fetal and Neonatal Medicine
    Volume14
    Issue number4
    DOIs
    StatePublished - Aug 2009

    Fingerprint

    Mycoplasma hominis
    Ureaplasma
    Opportunistic Infections
    Chorioamnionitis
    Bronchopulmonary Dysplasia
    Molecular Pathology
    Premature Obstetric Labor
    Lung Injury
    Bacteremia
    Meningitis
    Causality
    Observational Studies
    Virulence
    Pneumonia
    Newborn Infant
    Anti-Bacterial Agents
    Technology

    Keywords

    • Bronchopulmonary dysplasia
    • Chorioamnionitis
    • Congenital infection
    • Mycoplasma hominis
    • Preterm labor
    • Ureaplasma parvum
    • Ureaplasma urealyticum

    ASJC Scopus subject areas

    • Pediatrics, Perinatology, and Child Health

    Cite this

    Congenital and opportunistic infections : Ureaplasma species and Mycoplasma hominis. / Waites, Ken B.; Schelonka, Robert; Xiao, Li; Grigsby, Peta; Novy, Miles J.

    In: Seminars in Fetal and Neonatal Medicine, Vol. 14, No. 4, 08.2009, p. 190-199.

    Research output: Contribution to journalArticle

    Waites, Ken B. ; Schelonka, Robert ; Xiao, Li ; Grigsby, Peta ; Novy, Miles J. / Congenital and opportunistic infections : Ureaplasma species and Mycoplasma hominis. In: Seminars in Fetal and Neonatal Medicine. 2009 ; Vol. 14, No. 4. pp. 190-199.
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