Confirmation of CVS mosaicism in term placentae and high frequency of intrauterine growth retardation association with confined placental mosaicism

D. K. Kalousek, P. N. Howard-Peebles, Susan Olson, I. J. Barrett, A. Dorfmann, S. H. Black, J. D. Schulman, R. D. Wilson

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Abstract

About 2 per cent of specimens from chorionic villus sampling (CVS) analysed either on direct preparation of cytotrophoblast cells or after culture of mesenchymal stroma reveal confined placental mosaicism (CPM), most commonly involving chromosomal trisomy. A significantly higher rate of prenatal loss (22 per cent) as well as the presence of intrauterine growth retardation (IUGR) has been reported among pregnancies with CPM. To evaluate more precisely the effect of these aneuploid cell lines confined to the placenta on intrauterine fetal growth and fetal survival, we have studied 34 term placentae from pregnancies with CPM diagnosed on CVS and confirmed identical mosaicism in 17 of these placentae. There was a direct correlation between a higher number of aneuploid cells present at CVS and a high likelihood of their detection in term placenta. Also, the proportion of aneuploid cells in the mosaic term placentae correlatd with that observed in CVS specimens. Among 17 gestations with confirmed CPM at delivery, there were six cases of IUGR identified, five in liveborns and one associated with intrauterine death.

Original languageEnglish (US)
Pages (from-to)743-750
Number of pages8
JournalPrenatal Diagnosis
Volume11
Issue number10
StatePublished - 1991

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Chorionic Villi Sampling
Mosaicism
Fetal Growth Retardation
Placenta
Aneuploidy
Pregnancy
Trisomy
Trophoblasts
Fetal Development
Cell Line

ASJC Scopus subject areas

  • Genetics(clinical)
  • Obstetrics and Gynecology

Cite this

Kalousek, D. K., Howard-Peebles, P. N., Olson, S., Barrett, I. J., Dorfmann, A., Black, S. H., ... Wilson, R. D. (1991). Confirmation of CVS mosaicism in term placentae and high frequency of intrauterine growth retardation association with confined placental mosaicism. Prenatal Diagnosis, 11(10), 743-750.

Confirmation of CVS mosaicism in term placentae and high frequency of intrauterine growth retardation association with confined placental mosaicism. / Kalousek, D. K.; Howard-Peebles, P. N.; Olson, Susan; Barrett, I. J.; Dorfmann, A.; Black, S. H.; Schulman, J. D.; Wilson, R. D.

In: Prenatal Diagnosis, Vol. 11, No. 10, 1991, p. 743-750.

Research output: Contribution to journalArticle

Kalousek, DK, Howard-Peebles, PN, Olson, S, Barrett, IJ, Dorfmann, A, Black, SH, Schulman, JD & Wilson, RD 1991, 'Confirmation of CVS mosaicism in term placentae and high frequency of intrauterine growth retardation association with confined placental mosaicism', Prenatal Diagnosis, vol. 11, no. 10, pp. 743-750.
Kalousek, D. K. ; Howard-Peebles, P. N. ; Olson, Susan ; Barrett, I. J. ; Dorfmann, A. ; Black, S. H. ; Schulman, J. D. ; Wilson, R. D. / Confirmation of CVS mosaicism in term placentae and high frequency of intrauterine growth retardation association with confined placental mosaicism. In: Prenatal Diagnosis. 1991 ; Vol. 11, No. 10. pp. 743-750.
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