Conductance properties of GABA-activated chloride currents recorded from cultured hippocampal neurons

Charles Allen, E. X. Albuquerque

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The conductance characteristics of γ-aminobutyric acid-activated single channel currents from cultured hippocampal neurons were examined using patch clamp techniques. GABA-activated currents had amplitudes which were linearly correlated to the membrane potentials over a range of -80 to +70 mV and an open time and burst time of 2.2 and 4.3 ms, respectively. The conductance of the γ-aminobutyric acid-activated channels was 19 pS. These data demonstrate that cultured hippocampal neurons have channel conductances which have characteristics different from those of adult neurons.

Original languageEnglish (US)
Pages (from-to)159-163
Number of pages5
JournalBrain Research
Volume410
Issue number1
DOIs
StatePublished - Apr 28 1987
Externally publishedYes

Fingerprint

gamma-Aminobutyric Acid
Aminobutyrates
Chlorides
Neurons
Patch-Clamp Techniques
Membrane Potentials

Keywords

  • Amino acid
  • Cultured hippocampal pyramidal cell
  • Patch clamp recording
  • Single channel conductance
  • Single chloride channel
  • γ-Aminobutyric acid

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Conductance properties of GABA-activated chloride currents recorded from cultured hippocampal neurons. / Allen, Charles; Albuquerque, E. X.

In: Brain Research, Vol. 410, No. 1, 28.04.1987, p. 159-163.

Research output: Contribution to journalArticle

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