Conditioning regimens

Joseph Bubalo

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Abstract

    The preferred conditioning regimen should be capable of eliminating or reducing the tumor load from the malignant disorder, provide adequate immunosuppression to prevent graft rejection, and have manageable side effects or regimen-related toxicities. Traditionally, all allogeneic conditioning regimens were ablative, meaning that stem cell support was required in order to attain hematopoietic recovery of the bone marrow. More recently, there has been a trend in multiple patient populations to move toward reduced-intensity regimens (RIT), which are defined as any regimen that does not require stem cell support for hematopoietic recovery and results in low hematologic toxicity and mixed donor-recipient chimerism in a substantial proportion of patients in the early post-transplantation period.

    Original languageEnglish (US)
    Title of host publicationBlood and Marrow Transplant Handbook: Comprehensive Guide for Patient Care
    PublisherSpringer New York
    Pages39-49
    Number of pages11
    ISBN (Print)9781441975058
    DOIs
    StatePublished - 2011

    Fingerprint

    Chimerism
    Graft Rejection
    Hematopoietic Stem Cells
    Tumor Burden
    Immunosuppression
    Stem Cells
    Transplantation
    Bone Marrow
    Tissue Donors
    Population

    ASJC Scopus subject areas

    • Medicine(all)

    Cite this

    Bubalo, J. (2011). Conditioning regimens. In Blood and Marrow Transplant Handbook: Comprehensive Guide for Patient Care (pp. 39-49). Springer New York. https://doi.org/10.1007/978-1-4419-7506-5_5

    Conditioning regimens. / Bubalo, Joseph.

    Blood and Marrow Transplant Handbook: Comprehensive Guide for Patient Care. Springer New York, 2011. p. 39-49.

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Bubalo, J 2011, Conditioning regimens. in Blood and Marrow Transplant Handbook: Comprehensive Guide for Patient Care. Springer New York, pp. 39-49. https://doi.org/10.1007/978-1-4419-7506-5_5
    Bubalo J. Conditioning regimens. In Blood and Marrow Transplant Handbook: Comprehensive Guide for Patient Care. Springer New York. 2011. p. 39-49 https://doi.org/10.1007/978-1-4419-7506-5_5
    Bubalo, Joseph. / Conditioning regimens. Blood and Marrow Transplant Handbook: Comprehensive Guide for Patient Care. Springer New York, 2011. pp. 39-49
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