Concurrent heavy metal exposures and idiopathic dilated cardiomyopathy: A case-control study from the katanga mining area of the Democratic Republic of Congo

Didier Malamba-Lez, Désire Tshala-Katumbay, Virginie Bito, Jean Michel Rigo, Richie Kipenge Kyandabike, Eric Ngoy Yolola, Philippe Katchunga, Béatrice Koba-Bora, Dophra Ngoy-Nkulu

Research output: Contribution to journalArticlepeer-review

Abstract

Blood and/or urine levels of 27 heavy metals were determined by ICPMS in 41 patients with dilated cardiomyopathy (DCM) and 29 presumably healthy subjects from the Katanga Copperbelt (KC), in the Democratic Republic of Congo (DRC). After adjusting for age, gender, education level, and renal function, DCM probability was almost maximal for blood concentrations above 0.75 and 150 µg/dL for arsenic and copper, respectively. Urinary concentrations above 1 for chromium, 20 for copper, 600 for zinc, 30 for selenium, 2 for cadmium, 0.2 for antimony, 0.5 for thallium, and 0.05 for uranium, all in µg/g of creatinine, were also associated with increased DCM probability. Concurrent and multiple exposures to heavy metals, well beyond permissible levels, are associated with increased probability for DCM. Study findings warrant screening for metal toxicity in case of DCM and prompt public health measures to reduce exposures in the KC, DRC.

Original languageEnglish (US)
Article number4956
JournalInternational journal of environmental research and public health
Volume18
Issue number9
DOIs
StatePublished - May 1 2021

Keywords

  • Environmental exposures
  • Heavy metals
  • Idiopathic dilated cardiomyopathy
  • Katanga Copperbelt

ASJC Scopus subject areas

  • Pollution
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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