Concise synthesis and enzymatic resolution of L-(+)-homophenylalanine hydrochloride

Hua Zhao, Robert G. Luo, Dean Wei, Sanjay V. Malhotra

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

The N-acetyl-homophenylalanine ethyl ester was synthesized by a simple three-step-reaction strategy. L-(+)-homophenylalanine hydrochloride with 98% ee was obtained through a kinetic resolution process using industrial enzyme alcalase. Compared with other methods, this strategy has the advantage of economical and simple procedure giving high product optical purity.

Original languageEnglish (US)
Pages (from-to)1-3
Number of pages3
JournalEnantiomer
Volume7
Issue number1
DOIs
StatePublished - Jan 2002
Externally publishedYes

Keywords

  • Homophenylalanine
  • Kinetic resolution
  • Unnatural amino acids

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Organic Chemistry

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