Concise synthesis and enzymatic resolution of L-(+)-homophenylalanine hydrochloride

Hua Zhao; Robert G. Luo; Dean Wei; Sanjay V. Malhotra

doi:10.1080/10242430210706

Concise synthesis and enzymatic resolution of L-(+)-homophenylalanine hydrochloride

Hua Zhao, Robert G. Luo, Dean Wei, Sanjay V. Malhotra

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

The N-acetyl-homophenylalanine ethyl ester was synthesized by a simple three-step-reaction strategy. L-(+)-homophenylalanine hydrochloride with 98% ee was obtained through a kinetic resolution process using industrial enzyme alcalase. Compared with other methods, this strategy has the advantage of economical and simple procedure giving high product optical purity.

Original language	English (US)
Pages (from-to)	1-3
Number of pages	3
Journal	Enantiomer
Volume	7
Issue number	1
DOIs	https://doi.org/10.1080/10242430210706
State	Published - Jan 2002
Externally published	Yes

Keywords

Homophenylalanine
Kinetic resolution
Unnatural amino acids

ASJC Scopus subject areas

General Chemistry
Biochemistry
General Biochemistry, Genetics and Molecular Biology
Organic Chemistry

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10.1080/10242430210706

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abstract = "The N-acetyl-homophenylalanine ethyl ester was synthesized by a simple three-step-reaction strategy. L-(+)-homophenylalanine hydrochloride with 98% ee was obtained through a kinetic resolution process using industrial enzyme alcalase. Compared with other methods, this strategy has the advantage of economical and simple procedure giving high product optical purity.",

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AU - Wei, Dean

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AB - The N-acetyl-homophenylalanine ethyl ester was synthesized by a simple three-step-reaction strategy. L-(+)-homophenylalanine hydrochloride with 98% ee was obtained through a kinetic resolution process using industrial enzyme alcalase. Compared with other methods, this strategy has the advantage of economical and simple procedure giving high product optical purity.

KW - Homophenylalanine

KW - Kinetic resolution

KW - Unnatural amino acids

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Concise synthesis and enzymatic resolution of L-(+)-homophenylalanine hydrochloride

Abstract

Keywords

ASJC Scopus subject areas

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