Concise review: Parthenote stem cells for regenerative medicine: Genetic, epigenetic, and developmental features

Brittany Daughtry, Shoukhrat Mitalipov

    Research output: Contribution to journalArticle

    29 Scopus citations

    Abstract

    Embryonic stem cells (ESCs) have the potential to provide unlimited cells and tissues for regenerative medicine. ESCs derived from fertilized embryos, however, will most likely be rejected by a patient's immune system unless appropriately immunomatched. Pluripotent stem cells (PSCs) genetically identical to a patient can now be established by reprogramming of somatic cells. However, practical applications of PSCs for personalized therapies are projected to be unfeasible because of the enormous cost and time required to produce clinical-grade cells for each patient. ESCs derived from parthenogenetic embryos (pESCs) that are homozygous for human leukocyte antigens may serve as an attractive alternative for immunomatched therapies for a large population of patients. In this study, we describe the biology and genetic nature of mammalian parthenogenesis and review potential advantages and limitations of pESCs for cell-based therapies.

    Original languageEnglish (US)
    Pages (from-to)290-298
    Number of pages9
    JournalStem Cells Translational Medicine
    Volume3
    Issue number3
    DOIs
    StatePublished - 2014

    Keywords

    • Histocompatibility
    • Imprinting
    • Parthenogenesis
    • Pluripotent stem cells

    ASJC Scopus subject areas

    • Developmental Biology
    • Cell Biology

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