Concerted trafficking regulation of Kv2.1 and KATP channels by leptin in pancreatic β-cells

Yi Wu, Show-Ling Shyng, Pei Chun Chen

Research output: Contribution to journalArticle

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Abstract

Background: Leptin recruits KATP channels to the pancreatic β-cell membrane. Results: Leptin causes a parallel increase in Kv2.1 channel density that is dependent on AMPK, PKA, and actin depolymerization. Conclusion: Leptin signaling leads to simultaneous increases in KATP and Kv2.1 channel densities. Significance: Concerted KATP and Kv2.1 channel trafficking regulation by leptin may result in coordinated inhibition of β-cell excitability.

Original languageEnglish (US)
Pages (from-to)29676-29690
Number of pages15
JournalJournal of Biological Chemistry
Volume290
Issue number50
DOIs
Publication statusPublished - Dec 11 2015

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ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

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