Concerted trafficking regulation of Kv2.1 and KATP channels by leptin in pancreatic β-cells

Yi Wu; Show Ling Shyng; Pei Chun Chen

doi:10.1074/jbc.M115.670877

Concerted trafficking regulation of Kv2.1 and K_ATP channels by leptin in pancreatic β-cells

Yi Wu, Show Ling Shyng, Pei Chun Chen

Chemical Physiology and Biochemistry

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Background: Leptin recruits K_ATP channels to the pancreatic β-cell membrane. Results: Leptin causes a parallel increase in Kv2.1 channel density that is dependent on AMPK, PKA, and actin depolymerization. Conclusion: Leptin signaling leads to simultaneous increases in K_ATP and Kv2.1 channel densities. Significance: Concerted K_ATP and Kv2.1 channel trafficking regulation by leptin may result in coordinated inhibition of β-cell excitability.

Original language	English (US)
Pages (from-to)	29676-29690
Number of pages	15
Journal	Journal of Biological Chemistry
Volume	290
Issue number	50
DOIs	https://doi.org/10.1074/jbc.M115.670877
State	Published - Dec 11 2015

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M115.670877

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title = "Concerted trafficking regulation of Kv2.1 and KATP channels by leptin in pancreatic β-cells",

abstract = "Background: Leptin recruits KATP channels to the pancreatic β-cell membrane. Results: Leptin causes a parallel increase in Kv2.1 channel density that is dependent on AMPK, PKA, and actin depolymerization. Conclusion: Leptin signaling leads to simultaneous increases in KATP and Kv2.1 channel densities. Significance: Concerted KATP and Kv2.1 channel trafficking regulation by leptin may result in coordinated inhibition of β-cell excitability.",

author = "Yi Wu and Shyng, {Show Ling} and Chen, {Pei Chun}",

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AU - Shyng, Show Ling

AU - Chen, Pei Chun

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Y1 - 2015/12/11

N2 - Background: Leptin recruits KATP channels to the pancreatic β-cell membrane. Results: Leptin causes a parallel increase in Kv2.1 channel density that is dependent on AMPK, PKA, and actin depolymerization. Conclusion: Leptin signaling leads to simultaneous increases in KATP and Kv2.1 channel densities. Significance: Concerted KATP and Kv2.1 channel trafficking regulation by leptin may result in coordinated inhibition of β-cell excitability.

AB - Background: Leptin recruits KATP channels to the pancreatic β-cell membrane. Results: Leptin causes a parallel increase in Kv2.1 channel density that is dependent on AMPK, PKA, and actin depolymerization. Conclusion: Leptin signaling leads to simultaneous increases in KATP and Kv2.1 channel densities. Significance: Concerted KATP and Kv2.1 channel trafficking regulation by leptin may result in coordinated inhibition of β-cell excitability.

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Concerted trafficking regulation of Kv2.1 and K_ATP channels by leptin in pancreatic β-cells

Abstract

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