Conceptual Model to Illustrate the Symptom Experience and Humanistic Burden Associated with Atopic Dermatitis in Adults and Adolescents

Laura Grant, Lotte Seiding Larsen, Claire Trennery, Jonathan I. Silverberg, William Abramovits, Eric Simpson, Jean Francois Stalder, Jean Paty, Julie Hahn-Pedersen, Nana Kragh, Bo Bang, Rob Arbuckle

Research output: Contribution to journalArticle

Abstract

Atopic dermatitis (AD) is a pruritic or painful dermatologic disease characterized by xerosis and eczema lesions. The symptoms/signs of AD can significantly impact patients' health-related quality of life (HRQoL). This study aimed to qualitatively explore the adult and adolescent experience of AD. A targeted literature review and qualitative concept elicitation interviews with clinicians (n = 5), adult AD patients (n = 28), and adolescent AD patients (n = 20) were conducted to elicit AD signs/symptoms and HRQoL impacts experienced. Verbatim transcripts were analyzed using thematic analysis. Twenty-nine symptoms/signs of AD were reported, including pruritus, pain, erythema, and xerosis. Atopic dermatitis symptoms/signs were reported to substantially impact HRQoL. Scratching was reported to influence the experience of symptoms and HRQoL impacts. Four proximal impacts (including discomfort and sleep disturbance) were reported. Ten domains of distal impact were reported, including impacts on psychological and social functioning and activities of daily living. A conceptual model was developed to summarize these findings. This study highlights the range of symptoms and HRQoL impacts experienced by adults and adolescents with AD. To our knowledge, this study was first to explore the lived experience of AD in both adult and adolescent patients, providing valuable insight into the relatively unexplored adolescent experience of AD.

Original languageEnglish (US)
Pages (from-to)247-254
Number of pages8
JournalDermatitis
Volume30
Issue number4
DOIs
StatePublished - Jul 1 2019

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Atopic Dermatitis
Quality of Life
Signs and Symptoms
Eczema
Erythema
Pruritus
Activities of Daily Living
Sleep
Interviews
Psychology
Pain

ASJC Scopus subject areas

  • Immunology and Allergy
  • Dermatology

Cite this

Conceptual Model to Illustrate the Symptom Experience and Humanistic Burden Associated with Atopic Dermatitis in Adults and Adolescents. / Grant, Laura; Seiding Larsen, Lotte; Trennery, Claire; Silverberg, Jonathan I.; Abramovits, William; Simpson, Eric; Stalder, Jean Francois; Paty, Jean; Hahn-Pedersen, Julie; Kragh, Nana; Bang, Bo; Arbuckle, Rob.

In: Dermatitis, Vol. 30, No. 4, 01.07.2019, p. 247-254.

Research output: Contribution to journalArticle

Grant, L, Seiding Larsen, L, Trennery, C, Silverberg, JI, Abramovits, W, Simpson, E, Stalder, JF, Paty, J, Hahn-Pedersen, J, Kragh, N, Bang, B & Arbuckle, R 2019, 'Conceptual Model to Illustrate the Symptom Experience and Humanistic Burden Associated with Atopic Dermatitis in Adults and Adolescents', Dermatitis, vol. 30, no. 4, pp. 247-254. https://doi.org/10.1097/DER.0000000000000486
Grant, Laura ; Seiding Larsen, Lotte ; Trennery, Claire ; Silverberg, Jonathan I. ; Abramovits, William ; Simpson, Eric ; Stalder, Jean Francois ; Paty, Jean ; Hahn-Pedersen, Julie ; Kragh, Nana ; Bang, Bo ; Arbuckle, Rob. / Conceptual Model to Illustrate the Symptom Experience and Humanistic Burden Associated with Atopic Dermatitis in Adults and Adolescents. In: Dermatitis. 2019 ; Vol. 30, No. 4. pp. 247-254.
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