Concentration of human chorionic gonadotropin in the cerebrospinal fluid of patients with germinal cell hypothalamic tumors

R. M. Jordan, John Kendall, M. McClung, H. Kammer

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Plasma and cerebrospinal fluid (CSF) specimens were measured simultaneously for human chorionic gonadotropin (HCG) in two patients with HCG-secreting choriocarcinoma. In the patients with hypothalamic tumors, the CSF HCG levels were higher than the plasma HCG concentrations. In the patient with gestational choriocarcinoma with no known cerebral metastases, the plasma HCG level greatly exceeded the CSF HCG concentration. The finding of CSF HCG concentration that approaches or exceeds the plasma value would be a useful screening procedure in localizing a pathologic source of HCG secretion in patients with a suspected hypothalamic tumor. An unexpected finding in the patient who also had a hypothalamic embryonal cell carcinoma and hypocortisolism was an extremely high concentration of a biologically inactive adrenocorticotropic like substance in the CSF.

Original languageEnglish (US)
Pages (from-to)121-124
Number of pages4
JournalPediatrics
Volume65
Issue number1
StatePublished - 1980
Externally publishedYes

Fingerprint

Hypothalamic Neoplasms
Chorionic Gonadotropin
Cerebrospinal Fluid
Choriocarcinoma
Embryonal Carcinoma Stem Cells
Neoplasm Metastasis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Concentration of human chorionic gonadotropin in the cerebrospinal fluid of patients with germinal cell hypothalamic tumors. / Jordan, R. M.; Kendall, John; McClung, M.; Kammer, H.

In: Pediatrics, Vol. 65, No. 1, 1980, p. 121-124.

Research output: Contribution to journalArticle

Jordan, R. M. ; Kendall, John ; McClung, M. ; Kammer, H. / Concentration of human chorionic gonadotropin in the cerebrospinal fluid of patients with germinal cell hypothalamic tumors. In: Pediatrics. 1980 ; Vol. 65, No. 1. pp. 121-124.
@article{38347fb4c96c4239a898372000400398,
title = "Concentration of human chorionic gonadotropin in the cerebrospinal fluid of patients with germinal cell hypothalamic tumors",
abstract = "Plasma and cerebrospinal fluid (CSF) specimens were measured simultaneously for human chorionic gonadotropin (HCG) in two patients with HCG-secreting choriocarcinoma. In the patients with hypothalamic tumors, the CSF HCG levels were higher than the plasma HCG concentrations. In the patient with gestational choriocarcinoma with no known cerebral metastases, the plasma HCG level greatly exceeded the CSF HCG concentration. The finding of CSF HCG concentration that approaches or exceeds the plasma value would be a useful screening procedure in localizing a pathologic source of HCG secretion in patients with a suspected hypothalamic tumor. An unexpected finding in the patient who also had a hypothalamic embryonal cell carcinoma and hypocortisolism was an extremely high concentration of a biologically inactive adrenocorticotropic like substance in the CSF.",
author = "Jordan, {R. M.} and John Kendall and M. McClung and H. Kammer",
year = "1980",
language = "English (US)",
volume = "65",
pages = "121--124",
journal = "Pediatrics",
issn = "0031-4005",
publisher = "American Academy of Pediatrics",
number = "1",

}

TY - JOUR

T1 - Concentration of human chorionic gonadotropin in the cerebrospinal fluid of patients with germinal cell hypothalamic tumors

AU - Jordan, R. M.

AU - Kendall, John

AU - McClung, M.

AU - Kammer, H.

PY - 1980

Y1 - 1980

N2 - Plasma and cerebrospinal fluid (CSF) specimens were measured simultaneously for human chorionic gonadotropin (HCG) in two patients with HCG-secreting choriocarcinoma. In the patients with hypothalamic tumors, the CSF HCG levels were higher than the plasma HCG concentrations. In the patient with gestational choriocarcinoma with no known cerebral metastases, the plasma HCG level greatly exceeded the CSF HCG concentration. The finding of CSF HCG concentration that approaches or exceeds the plasma value would be a useful screening procedure in localizing a pathologic source of HCG secretion in patients with a suspected hypothalamic tumor. An unexpected finding in the patient who also had a hypothalamic embryonal cell carcinoma and hypocortisolism was an extremely high concentration of a biologically inactive adrenocorticotropic like substance in the CSF.

AB - Plasma and cerebrospinal fluid (CSF) specimens were measured simultaneously for human chorionic gonadotropin (HCG) in two patients with HCG-secreting choriocarcinoma. In the patients with hypothalamic tumors, the CSF HCG levels were higher than the plasma HCG concentrations. In the patient with gestational choriocarcinoma with no known cerebral metastases, the plasma HCG level greatly exceeded the CSF HCG concentration. The finding of CSF HCG concentration that approaches or exceeds the plasma value would be a useful screening procedure in localizing a pathologic source of HCG secretion in patients with a suspected hypothalamic tumor. An unexpected finding in the patient who also had a hypothalamic embryonal cell carcinoma and hypocortisolism was an extremely high concentration of a biologically inactive adrenocorticotropic like substance in the CSF.

UR - http://www.scopus.com/inward/record.url?scp=0018857278&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018857278&partnerID=8YFLogxK

M3 - Article

C2 - 6243767

AN - SCOPUS:0018857278

VL - 65

SP - 121

EP - 124

JO - Pediatrics

JF - Pediatrics

SN - 0031-4005

IS - 1

ER -