Computerized eeg frequency analysis: Sensitivity and specificity in patients with focal lesions

Barry Oken, Keith H. Chiappa, Martin Salinsky

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

We performed computerized EEG frequency analysis (C-EEGFA) in 69 controls and 20 patients with focal brain lesions and focally abnormal conventional EEGs. Individual channel EEG frequency analysis variables that were helpful in differentiating the 2 groups were absolute delta and theta band power, relative delta, theta, and alpha band powers, and median-power frequency. High-frequency beta band power (20 to 32 Hz) was not useful. Changes in EEG with age were seen only after age 50 and generally consisted of an increase in anterior alpha power, with no significant increase in slowing. Correlations of C-EEGFA variables with posterior alpha power were more significant than correlations with age. Calculating normative C-EEGFA data for 5 subsets of controls, each with a different amount of posterior alpha power, increased the sensitivity of the EEG frequency analysis test without altering the specificity. Even with this correction, 2 of 20 patients with focal lesions and focally abnormal conventional EEGs had normal C-EEGFA studies. If these obvious focal lesions produced normal results, more subtle diseases might not be detected. A significant clinical utility of C-EECFA remains to be proven.

Original languageEnglish (US)
Pages (from-to)1281-1287
Number of pages7
JournalNeurology
Volume39
Issue number10
StatePublished - 1989

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Electroencephalography
Sensitivity and Specificity
Specificity
Sensitivity Analysis
Lesion
Electroencephalogram
Brain

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Computerized eeg frequency analysis : Sensitivity and specificity in patients with focal lesions. / Oken, Barry; Chiappa, Keith H.; Salinsky, Martin.

In: Neurology, Vol. 39, No. 10, 1989, p. 1281-1287.

Research output: Contribution to journalArticle

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