Computerized acoustic cardiography correlates with echocardiography and invasive haemodynamics after percutaneous transvenous mitral commissurotomy

Background:Rheumatic mitral stenosis severity has been assessed by the systolic time interval between the QRS onset and the first heart sound (QS1) by phonocardiography. We hypothesized that non-invasive computerized acoustic cardiography could evaluate mitral stenosis severity compared with echocardiography and invasive haemodynamics in patients undergoing percutaneous transvenous mitral commissurotomy (PTMC). Methods:27 patients underwent computerized acoustic cardiography, echocardiography, and invasive haemodynamic measurements prior to and after PTMC. Results:The mean age was 31±10 years, and 21 (78%) were female. By echocardiography, mitral valve area increased from 0.82±0.14 to 1.50±0.24 cm² (p<0.0001). The QS1 interval decreased from 101.7±12.9 to 93.2±9.2ms (p<0.0001). The change in the QS1 interval correlated with the change in mitral valve area by echocardiography (p=0.037), right ventricular systolic pressure (p<0.0001), and the invasive mitral valve gradient (p=0.076). Conclusions:Acoustic cardiography may be used as an adjunctive non-invasive diagnostic tool to assess mitral stenosis severity.