Computer simulation of pressure wave generation in biological media by pulsed lasers with various beam profiles

Steven Jacques

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Pressure waves can be generated in biological tissues by pulsed lasers which deposit optical energy in absorbing structures such as blood vessels. Arrays of acoustic detectors on a tissue surface can sense the arrival of such waves. Analysis of the time-resolved signals can be used to reconstruct the 3-D distribution of the absorbing structures. In this report, a computer simulation was developed (see code listed in Appendix) to predict the time-resolved spatial distribution of pressure in a tissue in response to a pulse laser beam. In particular, the temporal history of pressure generated in a sphere of uniform energy deposition was calculated to illustrate the calibration of the computation. The temporal histories of pressures generated by a flat-field beam and a Gaussian-profile beam are also presented. The results show that the sharp edge of the flat-field beam yields tensile pressure wave and the pressure pattern is significantly different than the pressures produced by the smoother Gaussia-profile beam. The computer simulation is a very simple computation that is a valuable tool for predicting expected experimental results, and may be used in a reconstruction algorithm. This paper can be viewed at http://optics.sgu.ru/SFM/2002/internet/Jacques/index.htm.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsV.V. Tuchin
Pages92-103
Number of pages12
Volume5068
StatePublished - 2002
EventSaratov Fall Meeting 2002 Optical Technologies in Biophysics and Medicine IV - Saratov, Russian Federation
Duration: Oct 1 2002Oct 4 2002

Other

OtherSaratov Fall Meeting 2002 Optical Technologies in Biophysics and Medicine IV
CountryRussian Federation
CitySaratov
Period10/1/0210/4/02

Fingerprint

wave generation
Pulsed lasers
elastic waves
pulsed lasers
computerized simulation
Computer simulation
profiles
Tissue
histories
time signals
blood vessels
arrivals
Gaussian beams
spatial distribution
Blood vessels
deposits
laser beams
optics
Spatial distribution
Laser beams

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Jacques, S. (2002). Computer simulation of pressure wave generation in biological media by pulsed lasers with various beam profiles. In V. V. Tuchin (Ed.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 5068, pp. 92-103)

Computer simulation of pressure wave generation in biological media by pulsed lasers with various beam profiles. / Jacques, Steven.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / V.V. Tuchin. Vol. 5068 2002. p. 92-103.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Jacques, S 2002, Computer simulation of pressure wave generation in biological media by pulsed lasers with various beam profiles. in VV Tuchin (ed.), Proceedings of SPIE - The International Society for Optical Engineering. vol. 5068, pp. 92-103, Saratov Fall Meeting 2002 Optical Technologies in Biophysics and Medicine IV, Saratov, Russian Federation, 10/1/02.
Jacques S. Computer simulation of pressure wave generation in biological media by pulsed lasers with various beam profiles. In Tuchin VV, editor, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 5068. 2002. p. 92-103
Jacques, Steven. / Computer simulation of pressure wave generation in biological media by pulsed lasers with various beam profiles. Proceedings of SPIE - The International Society for Optical Engineering. editor / V.V. Tuchin. Vol. 5068 2002. pp. 92-103
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