Abstract
Pressure waves can be generated in biological tissues by pulsed lasers which deposit optical energy in absorbing structures such as blood vessels. Arrays of acoustic detectors on a tissue surface can sense the arrival of such waves. Analysis of the time-resolved signals can be used to reconstruct the 3-D distribution of the absorbing structures. In this report, a computer simulation was developed (see code listed in Appendix) to predict the time-resolved spatial distribution of pressure in a tissue in response to a pulse laser beam. In particular, the temporal history of pressure generated in a sphere of uniform energy deposition was calculated to illustrate the calibration of the computation. The temporal histories of pressures generated by a flat-field beam and a Gaussian-profile beam are also presented. The results show that the sharp edge of the flat-field beam yields tensile pressure wave and the pressure pattern is significantly different than the pressures produced by the smoother Gaussia-profile beam. The computer simulation is a very simple computation that is a valuable tool for predicting expected experimental results, and may be used in a reconstruction algorithm. This paper can be viewed at http://optics.sgu.ru/SFM/2002/internet/Jacques/index.htm.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 92-103 |
| Number of pages | 12 |
| Journal | Proceedings of SPIE - The International Society for Optical Engineering |
| Volume | 5068 |
| State | Published - Dec 1 2002 |
| Event | Saratov Fall Meeting 2002 Optical Technologies in Biophysics and Medicine IV - Saratov, Russian Federation Duration: Oct 1 2002 → Oct 4 2002 |
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Condensed Matter Physics
- Computer Science Applications
- Applied Mathematics
- Electrical and Electronic Engineering