Compromised respiratory function in postnatal lambs after placental insufficiency and intrauterine growth restriction

Belinda J. Joyce, Samantha Louey, Marcus G. Davey, Megan L. Cock, Stuart B. Hooper, Richard Harding

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Epidemiologic studies have shown persistent effects of low birth weight on respiratory function and lung health, but underlying mechanisms are not understood. Our aim was to determine the effects of intrauterine growth restriction (IUGR), a major cause of low birth weight, on postnatal respiratory function. IUGR was induced by umbilico-placental embolization during late gestation in chronically catheterized sheep. Umbilico-placental embolization was performed between 120 d of gestation and term (∼146 d) during which fetuses were hypoxemic and hypoglycemic relative to controls. Umbilico-placental embolization led to a 48% reduction in birth weight compared with controls, and throughout the postnatal study period IUGR lambs (n = 8) remained lighter than controls (n = 8). Respiratory function was repeatedly studied in lambs for 8 wk after birth; during this period, IUGR lambs were mildly hypoxemic and tended to be hypercapnic compared with controls. In IUGR lambs, relative to controls, O2 consumption (mL/min/kg) and minute ventilation (mL/kg) were increased and pulmonary diffusing capacity (adjusted for functional residual capacity) was decreased. Functional residual capacity, measured by helium dilution, and total lung capacity (measured at 30 cm H2O) were smaller in IUGR lambs than in controls. When adjusted for functional residual capacity, static lung compliance was reduced and chest wall compliance was increased in IUGR lambs. At 8 wk, pulmonary DNA and protein concentrations were decreased in IUGR lambs relative to controls. We conclude that restriction of fetal growth by placental insufficiency induces alterations in the lungs and chest wall that result in persistent impairments in respiratory function during early postnatal life.

Original languageEnglish (US)
Pages (from-to)641-649
Number of pages9
JournalPediatric Research
Volume50
Issue number5
StatePublished - 2001
Externally publishedYes

Fingerprint

Placental Insufficiency
Growth
Functional Residual Capacity
Low Birth Weight Infant
Thoracic Wall
Lung
Pulmonary Diffusing Capacity
Total Lung Capacity
Lung Compliance
Pregnancy
Helium
Fetal Development
Hypoglycemic Agents
Birth Weight
Compliance
Ventilation
Epidemiologic Studies
Sheep
Fetus
Parturition

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Joyce, B. J., Louey, S., Davey, M. G., Cock, M. L., Hooper, S. B., & Harding, R. (2001). Compromised respiratory function in postnatal lambs after placental insufficiency and intrauterine growth restriction. Pediatric Research, 50(5), 641-649.

Compromised respiratory function in postnatal lambs after placental insufficiency and intrauterine growth restriction. / Joyce, Belinda J.; Louey, Samantha; Davey, Marcus G.; Cock, Megan L.; Hooper, Stuart B.; Harding, Richard.

In: Pediatric Research, Vol. 50, No. 5, 2001, p. 641-649.

Research output: Contribution to journalArticle

Joyce, Belinda J. ; Louey, Samantha ; Davey, Marcus G. ; Cock, Megan L. ; Hooper, Stuart B. ; Harding, Richard. / Compromised respiratory function in postnatal lambs after placental insufficiency and intrauterine growth restriction. In: Pediatric Research. 2001 ; Vol. 50, No. 5. pp. 641-649.
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