Composite glandular-endocrine cell carcinoma of the common bile duct

Genichiro Edakuni; Eizaburo Sasatomi; Toshimi Satoh; Osamu Tokunaga; Kohji Miyazaki

doi:10.1046/j.1440-1827.2001.01227.x

Composite glandular-endocrine cell carcinoma of the common bile duct

Genichiro Edakuni, Eizaburo Sasatomi, Toshimi Satoh, Osamu Tokunaga, Kohji Miyazaki

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

A rare case of composite glandular-endocrine cell carcinoma of the common bile duct is presented. Histologically, this tumor consisted of adenocarcinoma and small-cell neuroendocrine carcinoma, with a transition between the two components. The two distinct areas of the tumor were immunohistochemically different, whereas the transitional zone exhibited characteristics of both areas. These features suggest that the tumor arose from a multipotential stem cell. Although it has been reported that the presence of neuroendocrine differentiation in carcinomas indicates a poor prognosis, the patient in the present case was well at the time of writing this report. This may be due to the fact that adenocarcinoma, which characteristically has a low proliferative activity, constituted the majority of the tumor.

Original language	English (US)
Pages (from-to)	487-490
Number of pages	4
Journal	Pathology International
Volume	51
Issue number	6
DOIs	https://doi.org/10.1046/j.1440-1827.2001.01227.x
State	Published - 2001
Externally published	Yes

Keywords

Adenocarcinoma
Common bile duct
Composite carcinoma
Endocrine cell carcinoma
Ki-67

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1046/j.1440-1827.2001.01227.x

Cite this

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title = "Composite glandular-endocrine cell carcinoma of the common bile duct",

abstract = "A rare case of composite glandular-endocrine cell carcinoma of the common bile duct is presented. Histologically, this tumor consisted of adenocarcinoma and small-cell neuroendocrine carcinoma, with a transition between the two components. The two distinct areas of the tumor were immunohistochemically different, whereas the transitional zone exhibited characteristics of both areas. These features suggest that the tumor arose from a multipotential stem cell. Although it has been reported that the presence of neuroendocrine differentiation in carcinomas indicates a poor prognosis, the patient in the present case was well at the time of writing this report. This may be due to the fact that adenocarcinoma, which characteristically has a low proliferative activity, constituted the majority of the tumor.",

keywords = "Adenocarcinoma, Common bile duct, Composite carcinoma, Endocrine cell carcinoma, Ki-67",

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T1 - Composite glandular-endocrine cell carcinoma of the common bile duct

AU - Edakuni, Genichiro

AU - Sasatomi, Eizaburo

AU - Satoh, Toshimi

AU - Tokunaga, Osamu

AU - Miyazaki, Kohji

PY - 2001

Y1 - 2001

N2 - A rare case of composite glandular-endocrine cell carcinoma of the common bile duct is presented. Histologically, this tumor consisted of adenocarcinoma and small-cell neuroendocrine carcinoma, with a transition between the two components. The two distinct areas of the tumor were immunohistochemically different, whereas the transitional zone exhibited characteristics of both areas. These features suggest that the tumor arose from a multipotential stem cell. Although it has been reported that the presence of neuroendocrine differentiation in carcinomas indicates a poor prognosis, the patient in the present case was well at the time of writing this report. This may be due to the fact that adenocarcinoma, which characteristically has a low proliferative activity, constituted the majority of the tumor.

AB - A rare case of composite glandular-endocrine cell carcinoma of the common bile duct is presented. Histologically, this tumor consisted of adenocarcinoma and small-cell neuroendocrine carcinoma, with a transition between the two components. The two distinct areas of the tumor were immunohistochemically different, whereas the transitional zone exhibited characteristics of both areas. These features suggest that the tumor arose from a multipotential stem cell. Although it has been reported that the presence of neuroendocrine differentiation in carcinomas indicates a poor prognosis, the patient in the present case was well at the time of writing this report. This may be due to the fact that adenocarcinoma, which characteristically has a low proliferative activity, constituted the majority of the tumor.

KW - Adenocarcinoma

KW - Common bile duct

KW - Composite carcinoma

KW - Endocrine cell carcinoma

KW - Ki-67

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Composite glandular-endocrine cell carcinoma of the common bile duct

Abstract

Keywords

ASJC Scopus subject areas

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