@article{ebd82571ef95405fb0be24541d144ddd,
title = "Complex-trait genetics: Emergence of multivariate strategies",
abstract = "Complex traits, including many disease-related traits, are influenced by multiple genes. Bivariate approaches that associate one gene with one trait are yielding to multivariate methods to synthesize the effects of multiple genes, integrate results across independent studies, and aid in the identification of coordinated pathways and interactions between loci.",
author = "Phillips, {Tamara J.} and Belknap, {John K.}",
note = "Funding Information: We are indebted to R. Hen for providing the breeding stocks of 5-HT1B mice. We are also grateful for the technical assistance of S. Burkhart-Kasch and A. Forster. We thank A. Palmer and J. Crabbe for insightful discussions. Our work is supported by grants from the Department of Veterans Affairs, the National Institute on Alcohol Abuse and Alcoholism, and the National Institute on Drug Abuse.",
year = "2002",
month = jun,
doi = "10.1038/nrn847",
language = "English (US)",
volume = "3",
pages = "478--485",
journal = "Nature Reviews Neuroscience",
issn = "1471-0048",
publisher = "Nature Publishing Group",
number = "6",
}