Complex karyotypic anomalies, including an i(5p) marker chromosome, in malignant mixed mesodermal tumor of the ovary

Tanja Pejovic; Sverre Heim; Nils Mandahl; Ulla Maria Flodérus; Helena Willén; Felix Mitelman

doi:10.1016/0165-4608(90)90009-Y

Complex karyotypic anomalies, including an i(5p) marker chromosome, in malignant mixed mesodermal tumor of the ovary

Tanja Pejovic, Sverre Heim, Nils Mandahl, Ulla Maria Flodérus, Helena Willén, Felix Mitelman

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Abstract

Cytogenetic analysis of short-term cultures initiated from an ovarian malignant mixed mesodermal tumor yielded the following karyotype: 59-61, XX,t(1;?)(p36;?), +t(1;9) (q43;q21), +t(2;?)(p25;?), +i(5p), +i(5p), +7, +t(7;?)(p13;?), +8,der(11) (pter→cen→q23::q13→q23::q13→q23::?), +12, +der(13)t(13;15)(q21;q15), -15,der(16) (16qter→cen→16p13::hsr::8q21→8qter), +19, +der(20)t(X;20)(q13;p13), -22, +4 -6mar. Because the only other cytogenetically characterized ovarian neoplasm of this rare histopathologic subtype also had a small metacentric marker interpreted as an isochromosome for the short arm of a B-group chromosome, we suggest that i(5p) constitutes a nonrandom anomaly in mixed mesodermal tumors.

Original language	English (US)
Pages (from-to)	65-69
Number of pages	5
Journal	Cancer Genetics and Cytogenetics
Volume	46
Issue number	1
DOIs	https://doi.org/10.1016/0165-4608(90)90009-Y
State	Published - May 1990
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

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title = "Complex karyotypic anomalies, including an i(5p) marker chromosome, in malignant mixed mesodermal tumor of the ovary",

abstract = "Cytogenetic analysis of short-term cultures initiated from an ovarian malignant mixed mesodermal tumor yielded the following karyotype: 59-61, XX,t(1;?)(p36;?), +t(1;9) (q43;q21), +t(2;?)(p25;?), +i(5p), +i(5p), +7, +t(7;?)(p13;?), +8,der(11) (pter→cen→q23::q13→q23::q13→q23::?), +12, +der(13)t(13;15)(q21;q15), -15,der(16) (16qter→cen→16p13::hsr::8q21→8qter), +19, +der(20)t(X;20)(q13;p13), -22, +4 -6mar. Because the only other cytogenetically characterized ovarian neoplasm of this rare histopathologic subtype also had a small metacentric marker interpreted as an isochromosome for the short arm of a B-group chromosome, we suggest that i(5p) constitutes a nonrandom anomaly in mixed mesodermal tumors.",

author = "Tanja Pejovic and Sverre Heim and Nils Mandahl and Flod{\'e}rus, {Ulla Maria} and Helena Will{\'e}n and Felix Mitelman",

note = "Funding Information: Supported by grants from the Swedish Cancer Society and the Swedish Work Environment Fund.",

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doi = "10.1016/0165-4608(90)90009-Y",

language = "English (US)",

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T1 - Complex karyotypic anomalies, including an i(5p) marker chromosome, in malignant mixed mesodermal tumor of the ovary

AU - Pejovic, Tanja

AU - Heim, Sverre

AU - Mandahl, Nils

AU - Flodérus, Ulla Maria

AU - Willén, Helena

AU - Mitelman, Felix

N1 - Funding Information: Supported by grants from the Swedish Cancer Society and the Swedish Work Environment Fund.

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Y1 - 1990/5

N2 - Cytogenetic analysis of short-term cultures initiated from an ovarian malignant mixed mesodermal tumor yielded the following karyotype: 59-61, XX,t(1;?)(p36;?), +t(1;9) (q43;q21), +t(2;?)(p25;?), +i(5p), +i(5p), +7, +t(7;?)(p13;?), +8,der(11) (pter→cen→q23::q13→q23::q13→q23::?), +12, +der(13)t(13;15)(q21;q15), -15,der(16) (16qter→cen→16p13::hsr::8q21→8qter), +19, +der(20)t(X;20)(q13;p13), -22, +4 -6mar. Because the only other cytogenetically characterized ovarian neoplasm of this rare histopathologic subtype also had a small metacentric marker interpreted as an isochromosome for the short arm of a B-group chromosome, we suggest that i(5p) constitutes a nonrandom anomaly in mixed mesodermal tumors.

AB - Cytogenetic analysis of short-term cultures initiated from an ovarian malignant mixed mesodermal tumor yielded the following karyotype: 59-61, XX,t(1;?)(p36;?), +t(1;9) (q43;q21), +t(2;?)(p25;?), +i(5p), +i(5p), +7, +t(7;?)(p13;?), +8,der(11) (pter→cen→q23::q13→q23::q13→q23::?), +12, +der(13)t(13;15)(q21;q15), -15,der(16) (16qter→cen→16p13::hsr::8q21→8qter), +19, +der(20)t(X;20)(q13;p13), -22, +4 -6mar. Because the only other cytogenetically characterized ovarian neoplasm of this rare histopathologic subtype also had a small metacentric marker interpreted as an isochromosome for the short arm of a B-group chromosome, we suggest that i(5p) constitutes a nonrandom anomaly in mixed mesodermal tumors.

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Complex karyotypic anomalies, including an i(5p) marker chromosome, in malignant mixed mesodermal tumor of the ovary

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