Complex karyotypic anomalies, including an i(5p) marker chromosome, in malignant mixed mesodermal tumor of the ovary

Tanja Pejovic, Sverre Heim, Nils Mandahl, Ulla Maria Flodérus, Helena Willén, Felix Mitelman

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Cytogenetic analysis of short-term cultures initiated from an ovarian malignant mixed mesodermal tumor yielded the following karyotype: 59-61, XX,t(1;?)(p36;?), +t(1;9) (q43;q21), +t(2;?)(p25;?), +i(5p), +i(5p), +7, +t(7;?)(p13;?), +8,der(11) (pter→cen→q23::q13→q23::q13→q23::?), +12, +der(13)t(13;15)(q21;q15), -15,der(16) (16qter→cen→16p13::hsr::8q21→8qter), +19, +der(20)t(X;20)(q13;p13), -22, +4 -6mar. Because the only other cytogenetically characterized ovarian neoplasm of this rare histopathologic subtype also had a small metacentric marker interpreted as an isochromosome for the short arm of a B-group chromosome, we suggest that i(5p) constitutes a nonrandom anomaly in mixed mesodermal tumors.

Original languageEnglish (US)
Pages (from-to)65-69
Number of pages5
JournalCancer Genetics and Cytogenetics
Volume46
Issue number1
DOIs
StatePublished - May 1990

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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