Complex karyotypic anomalies, including an i(5p) marker chromosome, in malignant mixed mesodermal tumor of the ovary

Tanja Pejovic, Sverre Heim, Nils Mandahl, Ulla Maria Flodérus, Helena Willén, Felix Mitelman

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Abstract

Cytogenetic analysis of short-term cultures initiated from an ovarian malignant mixed mesodermal tumor yielded the following karyotype: 59-61, XX,t(1;?)(p36;?), +t(1;9) (q43;q21), +t(2;?)(p25;?), +i(5p), +i(5p), +7, +t(7;?)(p13;?), +8,der(11) (pter→cen→q23::q13→q23::q13→q23::?), +12, +der(13)t(13;15)(q21;q15), -15,der(16) (16qter→cen→16p13::hsr::8q21→8qter), +19, +der(20)t(X;20)(q13;p13), -22, +4 -6mar. Because the only other cytogenetically characterized ovarian neoplasm of this rare histopathologic subtype also had a small metacentric marker interpreted as an isochromosome for the short arm of a B-group chromosome, we suggest that i(5p) constitutes a nonrandom anomaly in mixed mesodermal tumors.

Original languageEnglish (US)
Pages (from-to)65-69
Number of pages5
JournalCancer Genetics and Cytogenetics
Volume46
Issue number1
DOIs
StatePublished - 1990
Externally publishedYes

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ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

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