Complex karyotypic anomalies, including an i(5p) marker chromosome, in malignant mixed mesodermal tumor of the ovary

Tanja Pejovic, Sverre Heim, Nils Mandahl, Ulla Maria Flodérus, Helena Willén, Felix Mitelman

Research output: Contribution to journalArticle

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Cytogenetic analysis of short-term cultures initiated from an ovarian malignant mixed mesodermal tumor yielded the following karyotype: 59-61, XX,t(1;?)(p36;?), +t(1;9) (q43;q21), +t(2;?)(p25;?), +i(5p), +i(5p), +7, +t(7;?)(p13;?), +8,der(11) (pter→cen→q23::q13→q23::q13→q23::?), +12, +der(13)t(13;15)(q21;q15), -15,der(16) (16qter→cen→16p13::hsr::8q21→8qter), +19, +der(20)t(X;20)(q13;p13), -22, +4 -6mar. Because the only other cytogenetically characterized ovarian neoplasm of this rare histopathologic subtype also had a small metacentric marker interpreted as an isochromosome for the short arm of a B-group chromosome, we suggest that i(5p) constitutes a nonrandom anomaly in mixed mesodermal tumors.

Original languageEnglish (US)
Pages (from-to)65-69
Number of pages5
JournalCancer Genetics and Cytogenetics
Issue number1
StatePublished - 1990
Externally publishedYes


ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

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