Complex Genetic Architecture Underlies Regulation of Influenza-A-Virus-Specific Antibody Responses in the Collaborative Cross

Kelsey E. Noll, Alan C. Whitmore, Ande West, Mary K. McCarthy, Clayton R. Morrison, Kenneth S. Plante, Brea K. Hampton, Heike Kollmus, Carolin Pilzner, Sarah R. Leist, Lisa E. Gralinski, Vineet D. Menachery, Alexandra Schäfer, Darla Miller, Ginger Shaw, Michael Mooney, Shannon McWeeney, Fernando Pardo-Manuel de Villena, Klaus Schughart, Thomas E. MorrisonRalph S. Baric, Martin T. Ferris, Mark T. Heise

Research output: Contribution to journalArticle

Abstract

Noll et al. use the Collaborative Cross, a mouse genetic reference population, to map genetic loci associated with variation in the humoral response to influenza virus infection. Cross-dataset comparison shows that mapped loci are important for antibody response to multiple pathogens, and candidate genes with likely translational relevance are identified.

Original languageEnglish (US)
Article number107587
JournalCell Reports
Volume31
Issue number4
DOIs
StatePublished - Apr 28 2020

Keywords

  • Collaborative Cross
  • antibody
  • complex trait
  • genetic architecture
  • genetic mapping
  • genetic reference population
  • host genetics
  • humoral immunity
  • influenza
  • influenza virus

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Noll, K. E., Whitmore, A. C., West, A., McCarthy, M. K., Morrison, C. R., Plante, K. S., Hampton, B. K., Kollmus, H., Pilzner, C., Leist, S. R., Gralinski, L. E., Menachery, V. D., Schäfer, A., Miller, D., Shaw, G., Mooney, M., McWeeney, S., Pardo-Manuel de Villena, F., Schughart, K., ... Heise, M. T. (2020). Complex Genetic Architecture Underlies Regulation of Influenza-A-Virus-Specific Antibody Responses in the Collaborative Cross. Cell Reports, 31(4), [107587]. https://doi.org/10.1016/j.celrep.2020.107587