Complete heart block and death following lamotrigine overdose

Loren French, Nathanael J. McKeown, Robert Hendrickson

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Context. Lamotrigine is used for both seizure and psychiatric disorders. Overdoses typically follow a benign course. Case details. A 19-year-old male with bipolar disorder ingested 4 g of lamotrigine. The patient suffered from multiple seizures, charcoal aspiration, respiratory arrest, prolongaton of the QRS interval on electrocardiogram, complete heart block, multiorgan failure and ultimately death. Discussion. We describe the emergency department (ED) and ICU course for this patient and briefly review the toxic effects of lamotrigine and the pharmacokinetics with and without hemodialysis.

Original languageEnglish (US)
Pages (from-to)330-333
Number of pages4
JournalClinical Toxicology
Volume49
Issue number4
DOIs
StatePublished - Apr 2011

Fingerprint

Heart Block
Respiratory Aspiration
Intensive care units
Pharmacokinetics
Poisons
Charcoal
Electrocardiography
Bipolar Disorder
Psychiatry
Renal Dialysis
Hospital Emergency Service
Epilepsy
Seizures
lamotrigine

Keywords

  • Anticonvulsant
  • CNS/psychological
  • Dialysis
  • Heart

ASJC Scopus subject areas

  • Toxicology

Cite this

Complete heart block and death following lamotrigine overdose. / French, Loren; McKeown, Nathanael J.; Hendrickson, Robert.

In: Clinical Toxicology, Vol. 49, No. 4, 04.2011, p. 330-333.

Research output: Contribution to journalArticle

French, Loren ; McKeown, Nathanael J. ; Hendrickson, Robert. / Complete heart block and death following lamotrigine overdose. In: Clinical Toxicology. 2011 ; Vol. 49, No. 4. pp. 330-333.
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