TY - JOUR
T1 - Complete androgen insensitivity syndrome
T2 - An anatomic evaluation and sexual function questionnaire pilot study
AU - Wilson, Jason M.
AU - Arnhym, Anne
AU - Champeau, Angie
AU - Ebbers, Michele
AU - Coakley, Fergus
AU - Baskin, Laurence
PY - 2011/8
Y1 - 2011/8
N2 - Purpose: To further characterize the anatomy and sexual function of women with CAIS compared to normal females, and assess the utility of magnetic resonance imaging (MRI) to distinguish anatomical differences. Materials and methods: In a prospective cohort pilot study, five individuals with androgen insensitivity syndrome and six, normal, nulliparous women underwent an interview, physical examination, questionnaire completion and MRI of the pelvis. Statistical analysis was performed with emphasis on determining significant differences in anatomical findings and sexual satisfaction. Results: MRI demonstrated statistically significant differences in vaginal depth and size that were not confirmed on physical exam. MRI and physical exam demonstrated a non-significant difference in average phallic thickness between the two groups, although the CAIS group clitoral width tended to be smaller. Physical exam demonstrated a higher average erect height and longer arm span in the CAIS patients but this was not statistically significant. No significant differences were noted in categories designed to assess satisfaction with ability to achieve orgasm, vaginal appearance and frequency of sexual intercourse between the two groups. Conclusions: The women with CAIS were as satisfied with sexual function as were the women within the control group. Physical exam and MRI did not find any statistically significant clinically relevant differences between the two groups.
AB - Purpose: To further characterize the anatomy and sexual function of women with CAIS compared to normal females, and assess the utility of magnetic resonance imaging (MRI) to distinguish anatomical differences. Materials and methods: In a prospective cohort pilot study, five individuals with androgen insensitivity syndrome and six, normal, nulliparous women underwent an interview, physical examination, questionnaire completion and MRI of the pelvis. Statistical analysis was performed with emphasis on determining significant differences in anatomical findings and sexual satisfaction. Results: MRI demonstrated statistically significant differences in vaginal depth and size that were not confirmed on physical exam. MRI and physical exam demonstrated a non-significant difference in average phallic thickness between the two groups, although the CAIS group clitoral width tended to be smaller. Physical exam demonstrated a higher average erect height and longer arm span in the CAIS patients but this was not statistically significant. No significant differences were noted in categories designed to assess satisfaction with ability to achieve orgasm, vaginal appearance and frequency of sexual intercourse between the two groups. Conclusions: The women with CAIS were as satisfied with sexual function as were the women within the control group. Physical exam and MRI did not find any statistically significant clinically relevant differences between the two groups.
KW - Anatomic variation
KW - Complete androgen insensitivity syndrome
KW - MRI
KW - Phenotype
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U2 - 10.1016/j.jpurol.2010.07.002
DO - 10.1016/j.jpurol.2010.07.002
M3 - Article
C2 - 20719566
AN - SCOPUS:79958818121
SN - 1477-5131
VL - 7
SP - 416
EP - 421
JO - Journal of Pediatric Urology
JF - Journal of Pediatric Urology
IS - 4
ER -