Complete and partial aortic occlusion for the treatment of hemorrhagic shock in swine

Aaron M. Williams, Umar F. Bhatti, Isabel S. Dennahy, Kiril Chtraklin, Panpan Chang, Nathan J. Graham, Basil M. Baccouche, Shalini Roy, Mohammed Harajli, Jing Zhou, Vahagn C. Nikolian, Qiufang Deng, Yuzi Tian, Baoling Liu, Yongqing Li, Gregory L. Hays, Julia L. Hays, Hasan B. Alam

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Hemorrhage remains the leading cause of preventable deaths in trauma. Endovascular management of non-compressible torso hemorrhage has been at the forefront of trauma care in recent years. Since complete aortic occlusion presents serious concerns, the concept of partial aortic occlusion has gained a growing attention. Here, we present a large animal model of hemorrhagic shock to investigate the effects of a novel partial aortic balloon occlusion catheter and compare it with a catheter that works on the principles of complete aortic occlusion. Swine are anesthetized and instrumented in order to conduct controlled fixed-volume hemorrhage, and hemodynamic and physiological parameters are monitored. Following hemorrhage, aortic balloon occlusion catheters are inserted and inflated in the supraceliac aorta for 60 min, during which the animals receive whole-blood resuscitation as 20% of the total blood volume (TBV). Following balloon deflation, the animals are monitored in a critical care setting for 4 h, during which they receive fluid resuscitation and vasopressors as needed. The partial aortic balloon occlusion demonstrated improved distal mean arterial pressures (MAPs) during the balloon inflation, decreased markers of ischemia, and decreased fluid resuscitation and vasopressor use. As swine physiology and homeostatic responses following hemorrhage have been well-documented and are like those in humans, a swine hemorrhagic shock model can be used to test various treatment strategies. In addition to treating hemorrhage, aortic balloon occlusion catheters have become popular for their role in cardiac arrest, cardiac and vascular surgery, and other high-risk elective surgical procedures.

Original languageEnglish (US)
Article numbere58284
JournalJournal of Visualized Experiments
Volume2018
Issue number138
DOIs
StatePublished - Aug 24 2018
Externally publishedYes

Keywords

  • Aortic occlusion
  • Complete aortic occlusion
  • Hemorrhage
  • Hemorrhagic shock
  • Issue 138
  • Medicine
  • Partial aortic occlusion
  • Swine model

ASJC Scopus subject areas

  • Neuroscience(all)
  • Chemical Engineering(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Fingerprint

Dive into the research topics of 'Complete and partial aortic occlusion for the treatment of hemorrhagic shock in swine'. Together they form a unique fingerprint.

Cite this