Complementation between two temperaturesensitive mammalian cell mutants, each defective in the G1 phase of the cell cycle

R. Michael Liskay, Harriet K. Meiss

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Two mammalian temperature-sensitive (ts) G1cell cycle mutants of different species origin (Syrian hamster and mouse) have been tested for complementation using somatic cell hybrid analysis. All hamster-mouse hybrid clones tested were found to exhibit normal growth properties at the restrictive temperature, while neither mutant alone was capable of normal growth at this temperature. The two mutant lines therefore complement for growth in a somatic cell hybrid and most likely represent ts lesions in different cellular functions specific to the G1 phase of the cell cycle.

Original languageEnglish (US)
Pages (from-to)343-347
Number of pages5
JournalSomatic Cell Genetics
Volume3
Issue number3
DOIs
StatePublished - May 1 1977

ASJC Scopus subject areas

  • Genetics

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