Complementary carrier peptide synthesis: general strategy and implications for prebiotic origin of peptide synthesis.

J. A. Walder, R. Y. Walder, M. J. Heller, S. M. Freier, R. L. Letsinger, I. M. Klotz

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

A method for peptide synthesis is proposed based on a template-directed scheme that parallels that of the native ribosomal mechanism. In this procedure, peptide bond formation is facilitated by the juxtaposition of aminoacyl and peptidyl oligonucleotide carriers bound adjacent to one another on an oligonucleotide template. The general strategy of the synthesis and relevant model studies are described. The scheme provides an intrinsic mechanism by which oligonucleotides can direct the synthesis of polypeptides in the absence of protein or ribosomal machinery and, as such, suggests a model for the origin of prebiotic protein synthesis.

Original languageEnglish (US)
Pages (from-to)51-55
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume76
Issue number1
DOIs
StatePublished - Jan 1979

ASJC Scopus subject areas

  • General

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