Complement-Related Regulates Autophagy in Neighboring Cells

Lin Lin, Frederico S.L.M. Rodrigues, Christina Kary, Alicia Contet, Mary Logan, Richard H.G. Baxter, Will Wood, Eric H. Baehrecke

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Autophagy degrades cytoplasmic components and is important for development and human health. Although autophagy is known to be influenced by systemic intercellular signals, the proteins that control autophagy are largely thought to function within individual cells. Here, we report that Drosophila macroglobulin complement-related (Mcr), a complement ortholog, plays an essential role during developmental cell death and inflammation by influencing autophagy in neighboring cells. This function of Mcr involves the immune receptor Draper, suggesting a relationship between autophagy and the control of inflammation. Interestingly, Mcr function in epithelial cells is required for macrophage autophagy and migration to epithelial wounds, a Draper-dependent process. This study reveals, unexpectedly, that complement-related from one cell regulates autophagy in neighboring cells via an ancient immune signaling program.

Original languageEnglish (US)
Pages (from-to)158-171.e8
JournalCell
Volume170
Issue number1
DOIs
StatePublished - Jun 29 2017

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Macroglobulins
Autophagy
Macrophages
Cell death
Health
Inflammation
Human Development
Proteins
Drosophila
Cell Death
Epithelial Cells
Wounds and Injuries

Keywords

  • autophagy
  • complement
  • immune-receptor signaling
  • programmed cell death

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Lin, L., Rodrigues, F. S. L. M., Kary, C., Contet, A., Logan, M., Baxter, R. H. G., ... Baehrecke, E. H. (2017). Complement-Related Regulates Autophagy in Neighboring Cells. Cell, 170(1), 158-171.e8. https://doi.org/10.1016/j.cell.2017.06.018

Complement-Related Regulates Autophagy in Neighboring Cells. / Lin, Lin; Rodrigues, Frederico S.L.M.; Kary, Christina; Contet, Alicia; Logan, Mary; Baxter, Richard H.G.; Wood, Will; Baehrecke, Eric H.

In: Cell, Vol. 170, No. 1, 29.06.2017, p. 158-171.e8.

Research output: Contribution to journalArticle

Lin, L, Rodrigues, FSLM, Kary, C, Contet, A, Logan, M, Baxter, RHG, Wood, W & Baehrecke, EH 2017, 'Complement-Related Regulates Autophagy in Neighboring Cells', Cell, vol. 170, no. 1, pp. 158-171.e8. https://doi.org/10.1016/j.cell.2017.06.018
Lin L, Rodrigues FSLM, Kary C, Contet A, Logan M, Baxter RHG et al. Complement-Related Regulates Autophagy in Neighboring Cells. Cell. 2017 Jun 29;170(1):158-171.e8. https://doi.org/10.1016/j.cell.2017.06.018
Lin, Lin ; Rodrigues, Frederico S.L.M. ; Kary, Christina ; Contet, Alicia ; Logan, Mary ; Baxter, Richard H.G. ; Wood, Will ; Baehrecke, Eric H. / Complement-Related Regulates Autophagy in Neighboring Cells. In: Cell. 2017 ; Vol. 170, No. 1. pp. 158-171.e8.
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