Complement activation and kidney injury molecule-1-associated proximal tubule injury in severe preeclampsia

Richard Burwick, Sarah Rae Easter, Hassan Y. Dawood, Hidemi S. Yamamoto, Raina N. Fichorova, Bruce B. Feinberg

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Kidney injury with proteinuria is a characteristic feature of preeclampsia, yet the nature of injury in specific regions of the nephron is incompletely understood. Our study aimed to use existing urinary biomarkers to describe the pattern of kidney injury and proteinuria in pregnancies affected by severe preeclampsia. We performed a case-control study of pregnant women from Brigham and Women's Hospital from 2012 to 2013. We matched cases of severe preeclampsia (n=25) 1:1 by parity and gestational age to 2 control groups with and without chronic hypertension. Urinary levels of kidney injury molecule-1 and complement components (C3a, C5a, and C5b-9) were measured by enzyme-linked immunosorbent assay, and other markers (albumin, ß2 microglobulin, cystatin C, epithelial growth factor, neutrophil gelatinase-associated lipocalin, osteopontin, and uromodulin) were measured simultaneously with a multiplex electrochemiluminescence assay. Median values between groups were compared with the Wilcoxon signed-rank test and correlations with Spearman correlation coefficient. Analysis of urinary markers revealed higher excretion of albumin and kidney injury molecule-1 and lower excretion of neutrophil gelatinase-associated lipocalin and epithelial growth factor in severe preeclampsia compared with chronic hypertension and healthy controls. Among subjects with severe preeclampsia, urinary excretion of complement activation products correlated most closely with kidney injury molecule-1, a specific marker of proximal tubule injury (C5a: r=0.60; P=0.001; and C5b-9: r=0.75; P

Original languageEnglish (US)
Pages (from-to)833-838
Number of pages6
JournalHypertension
Volume64
Issue number4
DOIs
StatePublished - 2014

Fingerprint

Complement Activation
Pre-Eclampsia
Kidney
Wounds and Injuries
Complement Membrane Attack Complex
Proteinuria
Albumins
Intercellular Signaling Peptides and Proteins
Complement C3a
Uromodulin
Hypertension
Cystatin C
Osteopontin
Nephrons
Nonparametric Statistics
Parity
Gestational Age
Case-Control Studies
Pregnant Women
Biomarkers

Keywords

  • Complement membrane attack complex
  • Complement system proteins
  • Preeclampsia
  • Pregnancy

ASJC Scopus subject areas

  • Internal Medicine
  • Medicine(all)

Cite this

Burwick, R., Easter, S. R., Dawood, H. Y., Yamamoto, H. S., Fichorova, R. N., & Feinberg, B. B. (2014). Complement activation and kidney injury molecule-1-associated proximal tubule injury in severe preeclampsia. Hypertension, 64(4), 833-838. https://doi.org/10.1161/HYPERTENSIONAHA.114.03456

Complement activation and kidney injury molecule-1-associated proximal tubule injury in severe preeclampsia. / Burwick, Richard; Easter, Sarah Rae; Dawood, Hassan Y.; Yamamoto, Hidemi S.; Fichorova, Raina N.; Feinberg, Bruce B.

In: Hypertension, Vol. 64, No. 4, 2014, p. 833-838.

Research output: Contribution to journalArticle

Burwick, R, Easter, SR, Dawood, HY, Yamamoto, HS, Fichorova, RN & Feinberg, BB 2014, 'Complement activation and kidney injury molecule-1-associated proximal tubule injury in severe preeclampsia', Hypertension, vol. 64, no. 4, pp. 833-838. https://doi.org/10.1161/HYPERTENSIONAHA.114.03456
Burwick, Richard ; Easter, Sarah Rae ; Dawood, Hassan Y. ; Yamamoto, Hidemi S. ; Fichorova, Raina N. ; Feinberg, Bruce B. / Complement activation and kidney injury molecule-1-associated proximal tubule injury in severe preeclampsia. In: Hypertension. 2014 ; Vol. 64, No. 4. pp. 833-838.
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