Competition in retinogeniculate patterning driven by spontaneous activity

Anna A. Penn, Patricio Riquelme, Marla B. Feller, Carla J. Shatz

Research output: Contribution to journalArticle

367 Citations (Scopus)

Abstract

When contacts are first forming in the developing nervous system, many neurons generate spontaneous activity that has been hypothesized to shape appropriately patterned connections. In Mustela putorius furo, monocular intraocular blockade of spontaneous retinal waves of action potentials by cholinergic agents altered the subsequent eye-specific lamination pattern of the lateral geniculate nucleus (LGN). The projection from the active retina was greatly expanded into territory normally belonging to the other eye, and the projection from the inactive retina was substantially reduced. Thus, interocular competition driven by endogenous retinal activity determines the pattern of eye-specific connections from retina to LGN, demonstrating that spontaneous activity can produce highly stereotyped patterns of connections before the onset of visual experience.

Original languageEnglish (US)
Pages (from-to)2108-2112
Number of pages5
JournalScience
Volume279
Issue number5359
DOIs
StatePublished - Mar 27 1998
Externally publishedYes

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Geniculate Bodies
Retina
Ferrets
Cholinergic Agents
Nervous System
Action Potentials
Neurons

ASJC Scopus subject areas

  • General

Cite this

Penn, A. A., Riquelme, P., Feller, M. B., & Shatz, C. J. (1998). Competition in retinogeniculate patterning driven by spontaneous activity. Science, 279(5359), 2108-2112. https://doi.org/10.1126/science.279.5359.2108

Competition in retinogeniculate patterning driven by spontaneous activity. / Penn, Anna A.; Riquelme, Patricio; Feller, Marla B.; Shatz, Carla J.

In: Science, Vol. 279, No. 5359, 27.03.1998, p. 2108-2112.

Research output: Contribution to journalArticle

Penn, AA, Riquelme, P, Feller, MB & Shatz, CJ 1998, 'Competition in retinogeniculate patterning driven by spontaneous activity', Science, vol. 279, no. 5359, pp. 2108-2112. https://doi.org/10.1126/science.279.5359.2108
Penn, Anna A. ; Riquelme, Patricio ; Feller, Marla B. ; Shatz, Carla J. / Competition in retinogeniculate patterning driven by spontaneous activity. In: Science. 1998 ; Vol. 279, No. 5359. pp. 2108-2112.
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