Comparison of transillumination and histologic slide measurements of choroidal melanoma

James Umlas, Marie Diener-West, Nancy L. Robinson, W. Richard Green, Hans E. Grossnikelaus, Daniel Albert

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objective: To compare transillumination and histologic slide measurements of choroidal melanomas in 479 eyes randomized to enucleation in the Collaborative Ocular Melanoma Study. Design: Transillumination defects were measured during gross examination of enucleated eyes. Tumor basal diameter and height were measured on histologic slides and each tumor was assigned to 1 of 8 distinct shape categories. Comparison of the transillumination and histologic slide measurements revealed 3 categories of difference: underestimation (transillumination measurement more than 4 mm smaller than the histologic slide measurement), overestimation (transillumination measurement more than 4 mm larger than the histologic slide measurement), and agreement within 4 mm. Results: There was good correlation between transillumination and histologic slide estimates of largest basal diameter, particularly when the basal diameter was 16 mm or less. Measurement discrepancies were related to the shape of the tumors but not to the presence of subretinal fluid or fixation. Conclusions: Agreement was high between measurements of transillumination defect and histologic sections.

Original languageEnglish (US)
Pages (from-to)474-477
Number of pages4
JournalArchives of ophthalmology
Volume115
Issue number4
DOIs
StatePublished - Jan 1 1997
Externally publishedYes

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Transillumination
Melanoma
Subretinal Fluid
Neoplasms

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Comparison of transillumination and histologic slide measurements of choroidal melanoma. / Umlas, James; Diener-West, Marie; Robinson, Nancy L.; Green, W. Richard; Grossnikelaus, Hans E.; Albert, Daniel.

In: Archives of ophthalmology, Vol. 115, No. 4, 01.01.1997, p. 474-477.

Research output: Contribution to journalArticle

Umlas, James ; Diener-West, Marie ; Robinson, Nancy L. ; Green, W. Richard ; Grossnikelaus, Hans E. ; Albert, Daniel. / Comparison of transillumination and histologic slide measurements of choroidal melanoma. In: Archives of ophthalmology. 1997 ; Vol. 115, No. 4. pp. 474-477.
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N2 - Objective: To compare transillumination and histologic slide measurements of choroidal melanomas in 479 eyes randomized to enucleation in the Collaborative Ocular Melanoma Study. Design: Transillumination defects were measured during gross examination of enucleated eyes. Tumor basal diameter and height were measured on histologic slides and each tumor was assigned to 1 of 8 distinct shape categories. Comparison of the transillumination and histologic slide measurements revealed 3 categories of difference: underestimation (transillumination measurement more than 4 mm smaller than the histologic slide measurement), overestimation (transillumination measurement more than 4 mm larger than the histologic slide measurement), and agreement within 4 mm. Results: There was good correlation between transillumination and histologic slide estimates of largest basal diameter, particularly when the basal diameter was 16 mm or less. Measurement discrepancies were related to the shape of the tumors but not to the presence of subretinal fluid or fixation. Conclusions: Agreement was high between measurements of transillumination defect and histologic sections.

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