Comparison of traditional cardiovascular risk models and coronary atherosclerotic plaque as detected by computed tomography for prediction of acute coronary syndrome in patients with acute chest pain

Maros Ferencik, Christopher L. Schlett, Fabian Bamberg, Quynh A. Truong, John H. Nichols, Antonio J. Pena, Michael Shapiro, Ian S. Rogers, Sujith Seneviratne, Blair Alden Parry, Ricardo C. Cury, Thomas J. Brady, David F. Brown, John T. Nagurney, Udo Hoffmann

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Objectives: The objective was to determine the association of four clinical risk scores and coronary plaque burden as detected by computed tomography (CT) with the outcome of acute coronary syndrome (ACS) in patients with acute chest pain. The hypothesis was that the combination of risk scores and plaque burden improved the discriminatory capacity for the diagnosis of ACS. Methods: The study was a subanalysis of the Rule Out Myocardial Infarction Using Computer-Assisted Tomography (ROMICAT) trial-a prospective observational cohort study. The authors enrolled patients presenting to the emergency department (ED) with a chief complaint of acute chest pain, inconclusive initial evaluation (negative biomarkers, nondiagnostic electrocardiogram [ECG]), and no history of coronary artery disease (CAD). Patients underwent contrast-enhanced 64-multidetector-row cardiac CT and received standard clinical care (serial ECG, cardiac biomarkers, and subsequent diagnostic testing, such as exercise treadmill testing, nuclear stress perfusion imaging, and/or invasive coronary angiography), as deemed clinically appropriate. The clinical providers were blinded to CT results. The chest pain score was calculated and the results were dichotomized to ≥10 (high-risk) and

Original languageEnglish (US)
Pages (from-to)934-942
Number of pages9
JournalAcademic Emergency Medicine
Volume19
Issue number8
DOIs
StatePublished - Aug 2012
Externally publishedYes

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Cardiovascular Models
Acute Pain
Atherosclerotic Plaques
Acute Coronary Syndrome
Chest Pain
Tomography
Electrocardiography
Biomarkers
Perfusion Imaging
Multidetector Computed Tomography
Coronary Angiography
Observational Studies
Hospital Emergency Service
Coronary Artery Disease
Cohort Studies
Myocardial Infarction
Exercise

ASJC Scopus subject areas

  • Emergency Medicine

Cite this

Comparison of traditional cardiovascular risk models and coronary atherosclerotic plaque as detected by computed tomography for prediction of acute coronary syndrome in patients with acute chest pain. / Ferencik, Maros; Schlett, Christopher L.; Bamberg, Fabian; Truong, Quynh A.; Nichols, John H.; Pena, Antonio J.; Shapiro, Michael; Rogers, Ian S.; Seneviratne, Sujith; Parry, Blair Alden; Cury, Ricardo C.; Brady, Thomas J.; Brown, David F.; Nagurney, John T.; Hoffmann, Udo.

In: Academic Emergency Medicine, Vol. 19, No. 8, 08.2012, p. 934-942.

Research output: Contribution to journalArticle

Ferencik, M, Schlett, CL, Bamberg, F, Truong, QA, Nichols, JH, Pena, AJ, Shapiro, M, Rogers, IS, Seneviratne, S, Parry, BA, Cury, RC, Brady, TJ, Brown, DF, Nagurney, JT & Hoffmann, U 2012, 'Comparison of traditional cardiovascular risk models and coronary atherosclerotic plaque as detected by computed tomography for prediction of acute coronary syndrome in patients with acute chest pain', Academic Emergency Medicine, vol. 19, no. 8, pp. 934-942. https://doi.org/10.1111/j.1553-2712.2012.01417.x
Ferencik, Maros ; Schlett, Christopher L. ; Bamberg, Fabian ; Truong, Quynh A. ; Nichols, John H. ; Pena, Antonio J. ; Shapiro, Michael ; Rogers, Ian S. ; Seneviratne, Sujith ; Parry, Blair Alden ; Cury, Ricardo C. ; Brady, Thomas J. ; Brown, David F. ; Nagurney, John T. ; Hoffmann, Udo. / Comparison of traditional cardiovascular risk models and coronary atherosclerotic plaque as detected by computed tomography for prediction of acute coronary syndrome in patients with acute chest pain. In: Academic Emergency Medicine. 2012 ; Vol. 19, No. 8. pp. 934-942.
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