Abstract
We compared survival experiences for three groups with uveal melanoma: (1) 120 patients treated by proton beam irradiation from 1971; to 1981; (2) 235 patients treated by enucleation from 1953 to 1973 (enucleation group 1); and (3) 161 patients treated by enucleation from 1975 to 1981 (enucleation group 2). The following variables were predictive of melanoma-related deaths. Treatment: rate ratio (ratio of the rate of death for one category of the variable relative to the rate of death for another category) of 6.32 (95% confidence interval 1.70 to 23.51) for enucleation group 1 vs proton. beam, 3.06 (0.81 to 11.54) for enucleation group 2 vs proton beam, and 2.07 (1.05 to 4.07) for enuclea Lion group 1 vs enucleation group 2. Size: rate ratio of 3.61 (1.51 to 8.64) for large (16+ mm) vs small (<11 mm) tumors. Location: rate ratio of 3.19 (1.56 to 6.53) for tumors anterior vs posterior to the equator. When death from all causes was evaluated as the outcome, the estimated rate ratios were similar. When melanoma metastasis was evaluated as the outcome, the estimated rate ratios were reduced in magnitude.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 282-290 |
| Number of pages | 9 |
| Journal | American journal of ophthalmology |
| Volume | 99 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 15 1985 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Ophthalmology
Cite this
Comparison of survival rates for patients with uveal melanoma after treatment with proton beam irradiation or enucleation. / Seddon, Johanna M.; Gragoudas, Evangelos S.; Albert, Daniel; Hsieh, Chung Cheng; Polivogianis, Lela; Friedenberg, Georgina R.
In: American journal of ophthalmology, Vol. 99, No. 3, 15.03.1985, p. 282-290.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Comparison of survival rates for patients with uveal melanoma after treatment with proton beam irradiation or enucleation
AU - Seddon, Johanna M.
AU - Gragoudas, Evangelos S.
AU - Albert, Daniel
AU - Hsieh, Chung Cheng
AU - Polivogianis, Lela
AU - Friedenberg, Georgina R.
PY - 1985/3/15
Y1 - 1985/3/15
N2 - We compared survival experiences for three groups with uveal melanoma: (1) 120 patients treated by proton beam irradiation from 1971; to 1981; (2) 235 patients treated by enucleation from 1953 to 1973 (enucleation group 1); and (3) 161 patients treated by enucleation from 1975 to 1981 (enucleation group 2). The following variables were predictive of melanoma-related deaths. Treatment: rate ratio (ratio of the rate of death for one category of the variable relative to the rate of death for another category) of 6.32 (95% confidence interval 1.70 to 23.51) for enucleation group 1 vs proton. beam, 3.06 (0.81 to 11.54) for enucleation group 2 vs proton beam, and 2.07 (1.05 to 4.07) for enuclea Lion group 1 vs enucleation group 2. Size: rate ratio of 3.61 (1.51 to 8.64) for large (16+ mm) vs small (<11 mm) tumors. Location: rate ratio of 3.19 (1.56 to 6.53) for tumors anterior vs posterior to the equator. When death from all causes was evaluated as the outcome, the estimated rate ratios were similar. When melanoma metastasis was evaluated as the outcome, the estimated rate ratios were reduced in magnitude.
AB - We compared survival experiences for three groups with uveal melanoma: (1) 120 patients treated by proton beam irradiation from 1971; to 1981; (2) 235 patients treated by enucleation from 1953 to 1973 (enucleation group 1); and (3) 161 patients treated by enucleation from 1975 to 1981 (enucleation group 2). The following variables were predictive of melanoma-related deaths. Treatment: rate ratio (ratio of the rate of death for one category of the variable relative to the rate of death for another category) of 6.32 (95% confidence interval 1.70 to 23.51) for enucleation group 1 vs proton. beam, 3.06 (0.81 to 11.54) for enucleation group 2 vs proton beam, and 2.07 (1.05 to 4.07) for enuclea Lion group 1 vs enucleation group 2. Size: rate ratio of 3.61 (1.51 to 8.64) for large (16+ mm) vs small (<11 mm) tumors. Location: rate ratio of 3.19 (1.56 to 6.53) for tumors anterior vs posterior to the equator. When death from all causes was evaluated as the outcome, the estimated rate ratios were similar. When melanoma metastasis was evaluated as the outcome, the estimated rate ratios were reduced in magnitude.
UR - http://www.scopus.com/inward/record.url?scp=0021963323&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021963323&partnerID=8YFLogxK
U2 - 10.1016/0002-9394(85)90357-5
DO - 10.1016/0002-9394(85)90357-5
M3 - Article
VL - 99
SP - 282
EP - 290
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
SN - 0002-9394
IS - 3
ER -