Comparison of survival rates for patients with uveal melanoma after treatment with proton beam irradiation or enucleation

Johanna M. Seddon, Evangelos S. Gragoudas, Daniel Albert, Chung Cheng Hsieh, Lela Polivogianis, Georgina R. Friedenberg

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Abstract

We compared survival experiences for three groups with uveal melanoma: (1) 120 patients treated by proton beam irradiation from 1971; to 1981; (2) 235 patients treated by enucleation from 1953 to 1973 (enucleation group 1); and (3) 161 patients treated by enucleation from 1975 to 1981 (enucleation group 2). The following variables were predictive of melanoma-related deaths. Treatment: rate ratio (ratio of the rate of death for one category of the variable relative to the rate of death for another category) of 6.32 (95% confidence interval 1.70 to 23.51) for enucleation group 1 vs proton. beam, 3.06 (0.81 to 11.54) for enucleation group 2 vs proton beam, and 2.07 (1.05 to 4.07) for enuclea Lion group 1 vs enucleation group 2. Size: rate ratio of 3.61 (1.51 to 8.64) for large (16+ mm) vs small (<11 mm) tumors. Location: rate ratio of 3.19 (1.56 to 6.53) for tumors anterior vs posterior to the equator. When death from all causes was evaluated as the outcome, the estimated rate ratios were similar. When melanoma metastasis was evaluated as the outcome, the estimated rate ratios were reduced in magnitude.

Original languageEnglish (US)
Pages (from-to)282-290
Number of pages9
JournalAmerican journal of ophthalmology
Volume99
Issue number3
DOIs
StatePublished - Mar 15 1985
Externally publishedYes

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Protons
Survival Rate
Melanoma
Lions
Mortality
Cause of Death
Neoplasms
Therapeutics
Confidence Intervals
Neoplasm Metastasis
Survival
Uveal melanoma

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Comparison of survival rates for patients with uveal melanoma after treatment with proton beam irradiation or enucleation. / Seddon, Johanna M.; Gragoudas, Evangelos S.; Albert, Daniel; Hsieh, Chung Cheng; Polivogianis, Lela; Friedenberg, Georgina R.

In: American journal of ophthalmology, Vol. 99, No. 3, 15.03.1985, p. 282-290.

Research output: Contribution to journalArticle

Seddon, Johanna M. ; Gragoudas, Evangelos S. ; Albert, Daniel ; Hsieh, Chung Cheng ; Polivogianis, Lela ; Friedenberg, Georgina R. / Comparison of survival rates for patients with uveal melanoma after treatment with proton beam irradiation or enucleation. In: American journal of ophthalmology. 1985 ; Vol. 99, No. 3. pp. 282-290.
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