TY - JOUR
T1 - Comparison of structural magnetic resonance imaging and development in toddlers born very low birth weight and full-term
AU - Lowe, Jean
AU - Duvall, Susanne W.
AU - MacLean, Peggy C.
AU - Caprihan, Arvind
AU - Ohls, Robin
AU - Qualls, Clifford
AU - Phillips, John
PY - 2011/5
Y1 - 2011/5
N2 - Research suggests that regional structural differences can be associated with the neurodevelopmental impairments faced by children born very low birth weight. However, most studies have used magnetic resonance imaging (MRI) during the neonatal period or during adolescence. The current study used structural MRI to examine relationships between regional volume differences in toddlers (18-22 months adjusted age) born very low birth weight (n = 16) and full-term (n = 10) and neurodevelopmental outcomes, including cognition, language, and early executive functioning. Compared with the full-term group, the very low birth weight group had larger third ventricles and smaller cerebral white matter, thalamus, hippocampus, cerebellum white matter, and anterior cingulate volume. Additionally, a significant interaction was found between language and early executive function scores and cerebral white matter volumes between groups, suggesting that young children born very low birth weight can have different trajectories in the growth and development of overall brain structure.
AB - Research suggests that regional structural differences can be associated with the neurodevelopmental impairments faced by children born very low birth weight. However, most studies have used magnetic resonance imaging (MRI) during the neonatal period or during adolescence. The current study used structural MRI to examine relationships between regional volume differences in toddlers (18-22 months adjusted age) born very low birth weight (n = 16) and full-term (n = 10) and neurodevelopmental outcomes, including cognition, language, and early executive functioning. Compared with the full-term group, the very low birth weight group had larger third ventricles and smaller cerebral white matter, thalamus, hippocampus, cerebellum white matter, and anterior cingulate volume. Additionally, a significant interaction was found between language and early executive function scores and cerebral white matter volumes between groups, suggesting that young children born very low birth weight can have different trajectories in the growth and development of overall brain structure.
KW - brain volume
KW - development
KW - neuroimaging
KW - very low birth weight
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U2 - 10.1177/0883073810388418
DO - 10.1177/0883073810388418
M3 - Article
C2 - 21285034
AN - SCOPUS:79955582691
SN - 0883-0738
VL - 26
SP - 586
EP - 592
JO - Journal of child neurology
JF - Journal of child neurology
IS - 5
ER -