Comparison of structural magnetic resonance imaging and development in toddlers born very low birth weight and full-term

Jean Lowe, Susanne Duvall, Peggy C. MacLean, Arvind Caprihan, Robin Ohls, Clifford Qualls, John Phillips

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Research suggests that regional structural differences can be associated with the neurodevelopmental impairments faced by children born very low birth weight. However, most studies have used magnetic resonance imaging (MRI) during the neonatal period or during adolescence. The current study used structural MRI to examine relationships between regional volume differences in toddlers (18-22 months adjusted age) born very low birth weight (n = 16) and full-term (n = 10) and neurodevelopmental outcomes, including cognition, language, and early executive functioning. Compared with the full-term group, the very low birth weight group had larger third ventricles and smaller cerebral white matter, thalamus, hippocampus, cerebellum white matter, and anterior cingulate volume. Additionally, a significant interaction was found between language and early executive function scores and cerebral white matter volumes between groups, suggesting that young children born very low birth weight can have different trajectories in the growth and development of overall brain structure.

Original languageEnglish (US)
Pages (from-to)586-592
Number of pages7
JournalJournal of Child Neurology
Volume26
Issue number5
DOIs
StatePublished - May 2011
Externally publishedYes

Fingerprint

Very Low Birth Weight Infant
Magnetic Resonance Imaging
Language
Third Ventricle
Gyrus Cinguli
Executive Function
Thalamus
Growth and Development
Cerebellum
Cognition
Hippocampus
Brain
Research
White Matter

Keywords

  • brain volume
  • development
  • neuroimaging
  • very low birth weight

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health

Cite this

Comparison of structural magnetic resonance imaging and development in toddlers born very low birth weight and full-term. / Lowe, Jean; Duvall, Susanne; MacLean, Peggy C.; Caprihan, Arvind; Ohls, Robin; Qualls, Clifford; Phillips, John.

In: Journal of Child Neurology, Vol. 26, No. 5, 05.2011, p. 586-592.

Research output: Contribution to journalArticle

Lowe, Jean ; Duvall, Susanne ; MacLean, Peggy C. ; Caprihan, Arvind ; Ohls, Robin ; Qualls, Clifford ; Phillips, John. / Comparison of structural magnetic resonance imaging and development in toddlers born very low birth weight and full-term. In: Journal of Child Neurology. 2011 ; Vol. 26, No. 5. pp. 586-592.
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