TY - JOUR
T1 - Comparison of Several Atherogenicity Indices by the Analysis of Serum Lipoprptein Composition in Patients with Chronic Renal Failure with or without Haemodialysis, and in Renal Transplant Patients
AU - Lacour, B.
AU - Roullet, J. B.
AU - Beyne, P.
AU - Kreis, H.
AU - Thevenin, M.
AU - Drüeke, T.
N1 - Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 1985
Y1 - 1985
N2 - We investigated serum lipoproteins in uraemic and kidney transplant patients, and compared the results with those from normal persons. In uraemic patients, with or. without haemodialysis, and in kidney transplant patients, the ratio of HDL-cholesterol to total cholesterol minus HDL-cholesterol, the ratio of HDL-phospholipids to total phospholipids minus HDL-phospholipids, and the ratio of apolipoprotein A to apolipoprotein B are all decreased, though to different extents, when compared with healthy control subjects. Furthermore, important differences exist in the relative HDL composition between the 3 patient groups and healthy control subjects. Thus, the ratio of apolipoprotein A/HDL-cholesterol and that of HDL-cholesterol/HDL-phospholipids are significantly altered in uraemic haemodialyzed patients, while the ratio of apolipoprof tein A/HDL-phospholipids is normal. By contrast, the 3 ratios are normal in uraemic undialyzed patients, and the 2 ratios, apolipoprotein A/HDL-cholesterol and apolipoprotein A/HDL-phospholipids are normal in renal transplant patients. The last ratio, HDL-cholesterol/HDL-phospholipids, is increased in this group of patients. Thus, it appears that HDL-cholesterol, HDL-phospholipids, and total apolipoprotein A represent different aspects of the same lipoprotein. The determination of all three parameters could lead to a different approach in the evaluation of the so-called cardiovascular risk, at least for uraemic patients and renal transplant patients.
AB - We investigated serum lipoproteins in uraemic and kidney transplant patients, and compared the results with those from normal persons. In uraemic patients, with or. without haemodialysis, and in kidney transplant patients, the ratio of HDL-cholesterol to total cholesterol minus HDL-cholesterol, the ratio of HDL-phospholipids to total phospholipids minus HDL-phospholipids, and the ratio of apolipoprotein A to apolipoprotein B are all decreased, though to different extents, when compared with healthy control subjects. Furthermore, important differences exist in the relative HDL composition between the 3 patient groups and healthy control subjects. Thus, the ratio of apolipoprotein A/HDL-cholesterol and that of HDL-cholesterol/HDL-phospholipids are significantly altered in uraemic haemodialyzed patients, while the ratio of apolipoprof tein A/HDL-phospholipids is normal. By contrast, the 3 ratios are normal in uraemic undialyzed patients, and the 2 ratios, apolipoprotein A/HDL-cholesterol and apolipoprotein A/HDL-phospholipids are normal in renal transplant patients. The last ratio, HDL-cholesterol/HDL-phospholipids, is increased in this group of patients. Thus, it appears that HDL-cholesterol, HDL-phospholipids, and total apolipoprotein A represent different aspects of the same lipoprotein. The determination of all three parameters could lead to a different approach in the evaluation of the so-called cardiovascular risk, at least for uraemic patients and renal transplant patients.
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U2 - 10.1515/cclm.1985.23.12.805
DO - 10.1515/cclm.1985.23.12.805
M3 - Article
C2 - 3913738
AN - SCOPUS:84941835570
SN - 1434-6621
VL - 23
SP - 805
EP - 810
JO - Clinical Chemistry and Laboratory Medicine
JF - Clinical Chemistry and Laboratory Medicine
IS - 12
ER -