Vergleich mehrerer Atherogenitätsanzeichen durch Analyse der Zusammensetzung der Lipoproteine im Serum von Patienten mit chronischem Nierenversagen mit oder ohne Hämodialyse und nach Nierentransplantation

Translated title of the contribution: Comparison of Several Atherogenicity Indices by the Analysis of Serum Lipoprptein Composition in Patients with Chronic Renal Failure with or without Haemodialysis, and in Renal Transplant Patients

B. Lacour, Jean-Baptiste Roullet, P. Beyne, H. Kreis, M. Thevenin, T. Drüeke

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

We investigated serum lipoproteins in uraemic and kidney transplant patients, and compared the results with those from normal persons. In uraemic patients, with or. without haemodialysis, and in kidney transplant patients, the ratio of HDL-cholesterol to total cholesterol minus HDL-cholesterol, the ratio of HDL-phospholipids to total phospholipids minus HDL-phospholipids, and the ratio of apolipoprotein A to apolipoprotein B are all decreased, though to different extents, when compared with healthy control subjects. Furthermore, important differences exist in the relative HDL composition between the 3 patient groups and healthy control subjects. Thus, the ratio of apolipoprotein A/HDL-cholesterol and that of HDL-cholesterol/HDL-phospholipids are significantly altered in uraemic haemodialyzed patients, while the ratio of apolipoprof tein A/HDL-phospholipids is normal. By contrast, the 3 ratios are normal in uraemic undialyzed patients, and the 2 ratios, apolipoprotein A/HDL-cholesterol and apolipoprotein A/HDL-phospholipids are normal in renal transplant patients. The last ratio, HDL-cholesterol/HDL-phospholipids, is increased in this group of patients. Thus, it appears that HDL-cholesterol, HDL-phospholipids, and total apolipoprotein A represent different aspects of the same lipoprotein. The determination of all three parameters could lead to a different approach in the evaluation of the so-called cardiovascular risk, at least for uraemic patients and renal transplant patients.

Original languageUndefined
Pages (from-to)805-810
Number of pages6
JournalClinical Chemistry and Laboratory Medicine
Volume23
Issue number12
DOIs
StatePublished - 1985
Externally publishedYes

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Transplants
Chronic Kidney Failure
Renal Dialysis
Apolipoproteins A
Phospholipids
HDL Cholesterol
Kidney
Serum
Chemical analysis
Lipoproteins
Healthy Volunteers
Apolipoprotein A-II
Apolipoproteins B
Cholesterol
Control Groups

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Vergleich mehrerer Atherogenitätsanzeichen durch Analyse der Zusammensetzung der Lipoproteine im Serum von Patienten mit chronischem Nierenversagen mit oder ohne Hämodialyse und nach Nierentransplantation. / Lacour, B.; Roullet, Jean-Baptiste; Beyne, P.; Kreis, H.; Thevenin, M.; Drüeke, T.

In: Clinical Chemistry and Laboratory Medicine, Vol. 23, No. 12, 1985, p. 805-810.

Research output: Contribution to journalArticle

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abstract = "We investigated serum lipoproteins in uraemic and kidney transplant patients, and compared the results with those from normal persons. In uraemic patients, with or. without haemodialysis, and in kidney transplant patients, the ratio of HDL-cholesterol to total cholesterol minus HDL-cholesterol, the ratio of HDL-phospholipids to total phospholipids minus HDL-phospholipids, and the ratio of apolipoprotein A to apolipoprotein B are all decreased, though to different extents, when compared with healthy control subjects. Furthermore, important differences exist in the relative HDL composition between the 3 patient groups and healthy control subjects. Thus, the ratio of apolipoprotein A/HDL-cholesterol and that of HDL-cholesterol/HDL-phospholipids are significantly altered in uraemic haemodialyzed patients, while the ratio of apolipoprof tein A/HDL-phospholipids is normal. By contrast, the 3 ratios are normal in uraemic undialyzed patients, and the 2 ratios, apolipoprotein A/HDL-cholesterol and apolipoprotein A/HDL-phospholipids are normal in renal transplant patients. The last ratio, HDL-cholesterol/HDL-phospholipids, is increased in this group of patients. Thus, it appears that HDL-cholesterol, HDL-phospholipids, and total apolipoprotein A represent different aspects of the same lipoprotein. The determination of all three parameters could lead to a different approach in the evaluation of the so-called cardiovascular risk, at least for uraemic patients and renal transplant patients.",
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