Comparison of semantic and episodic memory BOLD fMRI activation in predicting cognitive decline in older adults

Nathan Hantke, Kristy A. Nielson, John L. Woodard, Leslie M. Guidotti Breting, Alissa Butts, Michael Seidenberg, J. Carson Smith, Sally Durgerian, Melissa Lancaster, Monica Matthews, Michael A. Sugarman, Stephen M. Rao

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Previous studies suggest that task-activated functional magnetic resonance imaging (fMRI) can predict future cognitive decline among healthy older adults. The present fMRI study examined the relative sensitivity of semantic memory (SM) versus episodic memory (EM) activation tasks for predicting cognitive decline. Seventy-eight cognitively intact elders underwent neuropsychological testing at entry and after an 18-month interval, with participants classified as cognitively Stable or Declining based on ≥1.0 SD decline in performance. Baseline fMRI scanning involved SM (famous name discrimination) and EM (name recognition) tasks. SM and EM fMRI activation, along with Apolipoprotein E (APOE) ε4 status, served as predictors of cognitive outcome using a logistic regression analysis. Twenty-seven (34.6%) participants were classified as Declining and 51 (65.4%) as Stable. APOE ε4 status alone significantly predicted cognitive decline (R2 =.106; C index =.642). Addition of SM activation significantly improved prediction accuracy (R2 =.285; C index =.787), whereas the addition of EM did not (R2 =.212; C index =.711). In combination with APOE status, SM task activation predicts future cognitive decline better than EM activation. These results have implications for use of fMRI in prevention clinical trials involving the identification of persons at-risk for age-associated memory loss and Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)11-21
Number of pages11
JournalJournal of the International Neuropsychological Society
Volume19
Issue number1
DOIs
StatePublished - Jan 1 2013
Externally publishedYes

Fingerprint

Episodic Memory
Semantics
Magnetic Resonance Imaging
Apolipoprotein E4
Names
Memory Disorders
Apolipoproteins E
Alzheimer Disease
Logistic Models
Regression Analysis
Cognitive Dysfunction
Clinical Trials

Keywords

  • Aging
  • Apolipoprotein-E
  • Longitudinal study
  • Magnetic resonance imaging
  • Memory loss
  • Mild cognitive impairment

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Comparison of semantic and episodic memory BOLD fMRI activation in predicting cognitive decline in older adults. / Hantke, Nathan; Nielson, Kristy A.; Woodard, John L.; Guidotti Breting, Leslie M.; Butts, Alissa; Seidenberg, Michael; Smith, J. Carson; Durgerian, Sally; Lancaster, Melissa; Matthews, Monica; Sugarman, Michael A.; Rao, Stephen M.

In: Journal of the International Neuropsychological Society, Vol. 19, No. 1, 01.01.2013, p. 11-21.

Research output: Contribution to journalArticle

Hantke, N, Nielson, KA, Woodard, JL, Guidotti Breting, LM, Butts, A, Seidenberg, M, Smith, JC, Durgerian, S, Lancaster, M, Matthews, M, Sugarman, MA & Rao, SM 2013, 'Comparison of semantic and episodic memory BOLD fMRI activation in predicting cognitive decline in older adults', Journal of the International Neuropsychological Society, vol. 19, no. 1, pp. 11-21. https://doi.org/10.1017/S1355617712000951
Hantke, Nathan ; Nielson, Kristy A. ; Woodard, John L. ; Guidotti Breting, Leslie M. ; Butts, Alissa ; Seidenberg, Michael ; Smith, J. Carson ; Durgerian, Sally ; Lancaster, Melissa ; Matthews, Monica ; Sugarman, Michael A. ; Rao, Stephen M. / Comparison of semantic and episodic memory BOLD fMRI activation in predicting cognitive decline in older adults. In: Journal of the International Neuropsychological Society. 2013 ; Vol. 19, No. 1. pp. 11-21.
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