Comparison of plaque- and flow cytometry-based methods for measuring dengue virus neutralization

Annette A. Kraus, William Messer, Laura B. Haymore, Aravinda M. De Silva

Research output: Contribution to journalArticle

104 Scopus citations

Abstract

As dengue vaccines enter clinical trials, there is a need for rapid and quantitative assays to measure neutralization. We have developed flow-based neutralization assays which generated results similar to those generated by the established, plaque reduction neutralization test. The flow assays are an improvement, as they use human cells and allow for high-throughput screening.

Original languageEnglish (US)
Pages (from-to)3777-3780
Number of pages4
JournalJournal of Clinical Microbiology
Volume45
Issue number11
DOIs
Publication statusPublished - Nov 2007
Externally publishedYes

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ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

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