Comparison of plaque- and flow cytometry-based methods for measuring dengue virus neutralization

Annette A. Kraus, William Messer, Laura B. Haymore, Aravinda M. De Silva

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

As dengue vaccines enter clinical trials, there is a need for rapid and quantitative assays to measure neutralization. We have developed flow-based neutralization assays which generated results similar to those generated by the established, plaque reduction neutralization test. The flow assays are an improvement, as they use human cells and allow for high-throughput screening.

Original languageEnglish (US)
Pages (from-to)3777-3780
Number of pages4
JournalJournal of Clinical Microbiology
Volume45
Issue number11
DOIs
StatePublished - Nov 2007
Externally publishedYes

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Dengue Vaccines
Neutralization Tests
Dengue Virus
Flow Cytometry
Clinical Trials

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

Cite this

Comparison of plaque- and flow cytometry-based methods for measuring dengue virus neutralization. / Kraus, Annette A.; Messer, William; Haymore, Laura B.; De Silva, Aravinda M.

In: Journal of Clinical Microbiology, Vol. 45, No. 11, 11.2007, p. 3777-3780.

Research output: Contribution to journalArticle

Kraus, Annette A. ; Messer, William ; Haymore, Laura B. ; De Silva, Aravinda M. / Comparison of plaque- and flow cytometry-based methods for measuring dengue virus neutralization. In: Journal of Clinical Microbiology. 2007 ; Vol. 45, No. 11. pp. 3777-3780.
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