Comparison of parenteral nutrition and enteral feeding with pectin in experimental colitis in the rat

R. H. Rolandelli, S. H. Saul, R. G. Settle, D. O. Jacobs, S. O. Trerotola, J. L. Rombeau

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The effect of a pectin-supplemented enteral diet on experimental colitis was compared with parenteral nutrition and with a pectin-free enteral diet. Forty-five rats had feeding catheters placed into either the stomach (IG, n=31) or the superior vena cava (IV, n=14) and then received acetic acid (colitis) or saline (control) enemas. After the enema, all rats received the same diet, either IG or IV, for 6 d except for 15 rats (IGP, 9 colitis and 6 controls), which had 1% pectin added to the diet. At the end of the feeding period the IGP group had significantly less colonic inflammation and/or necrosis than either IV (p<0.03) or IG (p<0.04) groups. Nitrogen balance, serum albumin, total iron-binding capacity and body weight did not differ significantly among dietary regimens. Thus, the degree of bowel injury in experimental colitis was decreased when animals were fed a pectin-supplemented enteral diet and this effect was independent of nutritional status.

Original languageEnglish (US)
Pages (from-to)715-721
Number of pages7
JournalAmerican Journal of Clinical Nutrition
Issue number4
StatePublished - Jan 1 1988


ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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